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J-GLOBAL ID：201802246569255313   Reference number：18A2063744

A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a β-sheet rich oligomer

位置210でのバリンからリジンへの置換はプリオン蛋白質のβシートに富むオリゴマへの構造変換を誘導する【JST・京大機械翻訳】

Author (5)： Kakuda Kyosuke (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan) ,  Yamaguchi Kei-ichi (Institute for Protein Research, Osaka University, Yamadaoka 3-2, Suita, Osaka, 565-0871, Japan) ,  Kuwata Kazuo (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan) ,  Kuwata Kazuo (Department of Gene and Development, Graduate School of Medicine, Gifu University, Gifu, 501-1193, Japan) ,  Honda Ryo (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 506  Issue： 1  Page： 81-86  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Prion diseases are fatal neuro...

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Thesaurus term： amino acid residue ,  *oligomer ,  electric charge ,  Dynamic Light Scattering ,  prion disease ,  *Prions ,  electron microscopy ,  Fluorescence ,  Mutation ,  characterization ,  *beta-structure ,  hydrophobic ,  isoform ,  alpha helix ,  *Proteins ,  *glycoprotein ,  *prion protein ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine
Semi thesaurus term： 残基 , 【Automatic Indexing@JST】

Author keywords (4)： Protein folding ,  Prion ,  Amyloid ,  Protein aggregation

JST classification (2)： Cell components in general  (EF03010Z) ,  Molecular structure  (EB03020Y)

Substance index (1)： Lysine

Terms in the title (6)： バリン ,  リジン ,  置換 ,  プリオン蛋白質 ,  オリゴマ ,  誘導