Art

J-GLOBAL ID：201802250003068714   Reference number：18A1504146

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms

DNA修復経路を欠く同質遺伝子性ヒト細胞における異なる小核頻度は遺伝毒性剤の評価とそれらの遺伝毒性機構を示す価値ある指標である【JST・京大機械翻訳】

Author (13)： Saha Liton Kumar (Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Kim Sujin (Department of Environmental Health, School of Public Health, Seoul National University,599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea) ,  Kang Habyeong (Department of Environmental Health, School of Public Health, Seoul National University,599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea) ,  Akter Salma (Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Choi Kyungho (Department of Environmental Health, School of Public Health, Seoul National University,599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea) ,  Sakuma Tetsushi (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, 739-8526, Japan) ,  Yamamoto Takashi (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, 739-8526, Japan) ,  Sasanuma Hiroyuki (Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Hirota Kouji (Department of Chemistry, Tokyo Metropolitan University, Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan) ,  Nakamura Jun (Department of Laboratory Animal Science, School of Veterinary Science, Osaka Prefecture University, Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan) ,  Honma Masamitsu (Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan) ,  Takeda Shunichi (Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Dertinger S.
Material： Environmental and Molecular Mutagenesis  (Environ Mol Mutagen)
Volume： 59  Issue： 6  Page： 529-538  Publication year： 2018 
JST Material Number： W0213A  ISSN： 0893-6692  CODEN： EMMUEG  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The micronucleus (MN) test has...

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Thesaurus term： *gene ,  *genetic toxicity ,  Chromosome Aberrations ,  wild type ,  chemical substance ,  gamma-ray ,  excision repair ,  *human ,  DNA double strand break ,  Hydrogen Peroxide ,  *micronucleus ,  TK6 cell ,  XRCC1 ,  Aneuploidy ,  *isogene ,  cellular genetic phenomenon

Author keywords (3)： In vitro micronucleus assay ,  DNA-repair-deficient TK6 cell ,  DNA-damaging agent

JST classification (1)： Genetic variation  (EC01030Y)

Terms in the title (11)： DNA修復 ,  経路 ,  同質遺伝子 ,  ヒト ,  細胞 ,  小核 ,  頻度 ,  遺伝毒性 ,  評価 ,  価値 ,  指標