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J-GLOBAL ID：201802251695960824   Reference number：18A1757292

Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones

Eggerthella sp.YY7918のダイゼインレダクターゼ,FMN/FAD/4Fe-4Sを含むその八量体サブユニット構造及びR-ジヒドロイソフラボンのそのエナンチオ選択的生産

Author (17)： Kawada Yuika (United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Goshima Tomoko (Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Sawamura Rie (Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Yokoyama Shin-ichiro (Department of Food Technology, Industrial Technology Center, Gifu Prefectural Government, 47 Kitaoyobi, Kasamatsu, Hashima, Gifu 501-6064, Japan) ,  Yanase Emiko (Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Niwa Toshio (Faculty of Health and Nutrition, Shubun University, 6 Nikko-cho, Ichinomiya, Aichi 491-0938, Japan) ,  Ebihara Akio (United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Ebihara Akio (Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Ebihara Akio (Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Inagaki Mizuho (Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Yamaguchi Keiichi (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Kuwata Kazuo (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Kuwata Kazuo (Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Kato Yuta (Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Sakurada Osamu (Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Suzuki Tohru (United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  Suzuki Tohru (Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 126  Issue： 3  Page： 301-309  Publication year： Sep. 2018 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： recombinant protein ,...
Semi thesaurus term： *Enterobacteriaceae ,...

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Author keywords (9)： Isoflavone ,  Equol ,  Gut microflora ,  Small-angle X-ray scattering ,  Reductase ,  NADPH ,  FAD ,  FMN ,  Old yellow enzyme

JST classification (2)： Substance production by microorganisms,cultured tissues/cells in general  (FK03010P) ,  Enzyme physiology  (EG03052C)

Substance index (7)： Daidzein ,  (S)-Equol ,  Dihydrodaidzein ,  Genistein ,  Formononetin ,  Glycitein ,  Dihydrogenistein

Reference (52)：

• Lagari, V. S. and Levis, S.: Phytoestrogens for menopausal bone loss and climacteric symptoms, J. Steroid Biochem. Mol. Biol., 139, 294-301 (2014).
• Uifălean, A., Schneider, S., Ionescu, C., Lalk, M., and Iugs, C. A.: Soy isoflavones and breast cancer cell lines: molecular mechanisms and future perspectives, Molecules, 21, E13 (2015).
• Bowey, E., Adlercreutz, H., and Rowland, I.: Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats, Food Chem. Toxicol., 41, 631-636 (2003).
• Sathyamoorthy, N. and Wang, T.: Differential effects of dietary phytooestrogens daidzein and equol on human breast cancer MCF-7 cells, Eur. J. Canc., 33, 2384-2389 (1997).
• Setchell, K. D. R. and Clerici, C.: Equol: history, chemistry, and formation, J. Nutr., 140, 13555-1362S (2010).

Terms in the title (4)： FMN ,  FAD ,  八量体 ,  サブユニット