Art

J-GLOBAL ID：201802257690626690   Reference number：18A1228762

Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan

日本の発作性夜間ヘモグロビン尿症患者における生活の質に対するエクリズマブ治療の効果

Author (34)： UEDA Yasutaka (Osaka Univ., Osaka, JPN) ,  UEDA Yasutaka (Japan PNH Study Group, Tokyo, JPN) ,  OBARA Naoshi (Japan PNH Study Group, Tokyo, JPN) ,  OBARA Naoshi (Univ. Tsukuba, Tsukuba, JPN) ,  YONEMURA Yuji (Japan PNH Study Group, Tokyo, JPN) ,  YONEMURA Yuji (Kumamoto Univ. Hospital, Kumamoto, JPN) ,  NOJI Hideyoshi (Japan PNH Study Group, Tokyo, JPN) ,  NOJI Hideyoshi (Fukushima Medical Univ., Fukushima, JPN) ,  MASUKO Masayoshi (Niigata Univ. Hospital, Niigata, JPN) ,  SEKI Yoshinobu (Niigata Prefectural Shibata Hospital, Shibata, JPN) ,  SEKI Yoshinobu (Niigata Univ. Medical and Dental Hospital, Minami-Uonuma, JPN) ,  WADA Katsuya (Matsushita Memorial Hospital, Moriguchi, JPN) ,  MATSUDA Takahisa (Alexion Pharma G.K, Tokyo, JPN) ,  AKIYAMA Hirozumi (Alexion Pharma G.K, Tokyo, JPN) ,  IKEZOE Takayuki (Japan PNH Study Group, Tokyo, JPN) ,  IKEZOE Takayuki (Fukushima Medical Univ., Fukushima, JPN) ,  CHIBA Shigeru (Japan PNH Study Group, Tokyo, JPN) ,  CHIBA Shigeru (Univ. Tsukuba, Tsukuba, JPN) ,  KANDA Yoshinobu (Japan PNH Study Group, Tokyo, JPN) ,  KANDA Yoshinobu (Jichi Medical Univ., Shimotsuke, JPN) ,  KAWAGUCHI Tatsuya (Japan PNH Study Group, Tokyo, JPN) ,  KAWAGUCHI Tatsuya (Kumamoto Univ., Kumamoto, JPN) ,  SHICHISHIMA Tsutomu (Japan PNH Study Group, Tokyo, JPN) ,  SHICHISHIMA Tsutomu (Fukushima Medical Univ., Fukushima, JPN) ,  NAKAKUMA Hideki (Japan PNH Study Group, Tokyo, JPN) ,  NAKAKUMA Hideki (Kagoshima Tokusyukai Hospital, Kagoshima, JPN) ,  OKAMOTO Shinichiro (Japan PNH Study Group, Tokyo, JPN) ,  OKAMOTO Shinichiro (Keio Univ. School of Medicine, Tokyo, JPN) ,  NISHIMURA Jun-ichi (Osaka Univ., Osaka, JPN) ,  NISHIMURA Jun-ichi (Japan PNH Study Group, Tokyo, JPN) ,  KANAKURA Yuzuru (Osaka Univ., Osaka, JPN) ,  KANAKURA Yuzuru (Japan PNH Study Group, Tokyo, JPN) ,  NINOMIYA Haruhiko (Japan PNH Study Group, Tokyo, JPN) ,  NINOMIYA Haruhiko (Univ. Tsukuba, Tsukuba, JPN)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 107  Issue： 6  Page： 656-665  Publication year： Jun. 2018 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *Paroxysmal nocturnal hemoglobinuria ,...

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JST classification (1)： Drug therapy(=pharmacotherapy)for hematologic diseases in general  (GK05020P)

Reference (18)：

• Miyata T, Yamada N, Iida Y, Nishimura J, Takeda J, Kitani T, et al. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1994;330:249-55.
• Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293:1653-62.
• Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-709.
• Schrezenmeier H, Muus P, Socié G, Szer J, Urbano-Ispizua A, Maciejewski JP, et al. Baseline characteristics and disease burden in patients in the International Paroxysmal Nocturnal Hemoglobinuria Registry. Haematologica. 2014;99:922-9.
• Almeida AM, Bedrosian C, Cole A, Muus P, Schrezenmeier H, Szer J, et al. Clinical benefit of eculizumab in patients with no transfusion history in the International Paroxysmal Nocturnal Haemoglobinuria Registry. Intern Med J. 2017;47:1026-34.

Terms in the title (6)： 日本 ,  発作性夜間ヘモグロビン尿症 ,  患者 ,  生活の質 ,  エクリズマブ ,  治療