Art

J-GLOBAL ID：201802262952270071   Reference number：18A2052390

A randomized phase II study evaluating pyridoxine for the prevention of hand-foot syndrome associated with capecitabine therapy for advanced or metastatic breast cancer

進行または転移乳癌のためのカペシタビン療法と関連した手足症候群の予防のためのピリドキシンを評価したランダム化第II相試験

Author (11)： TOYAMA Tatsuya (Nagoya City Univ. Graduate School of Medical Sci., Nagoya, JPN) ,  YOSHIMURA Akiyo (Aichi Cancer Center Hospital, Nagoya, JPN) ,  HAYASHI Takako (Nagoya Medical Center, Nagoya, JPN) ,  KOBAYASHI Naomi (Fujita Health Univ., Toyoake, JPN) ,  SAITO Kanako (Mie Univ., Tsu, JPN) ,  TSUNEIZUMI Michiko (Shizuoka General Hospital, Shizuoka, JPN) ,  SAWAKI Masataka (Aichi Cancer Center Hospital, Nagoya, JPN) ,  HATTORI Masaya (Aichi Cancer Center Hospital, Nagoya, JPN) ,  NAKADA Takumi (Gifu Municipal Hospital, Gifu, JPN) ,  YOKOTA Isao (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  IWATA Hiroji (Aichi Cancer Center Hospital, Nagoya, JPN)
Material： Breast Cancer
Volume： 25  Issue： 6  Page： 729-735  Publication year： Nov. 2018 
JST Material Number： L3971A  ISSN： 1340-6868  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *vitamin B family ,...
Semi thesaurus term： *Hand-Foot Syndrome

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JST classification (2)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Skin diseases  (GF03000Q)

Substance index (2)： Vitamin B6 ,  Capecitabine

Reference (14)：

• Zuehlke RL. Erythematous eruption of the palms and soles associated with mitotane therapy. Dermatologica. 1974;148:90-2.
• Lipworth AD, Robert C, Zhu AX. Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib. Oncology. 2009;77:257-71.
• Abushullaih S, Saad ED, Munsell M, Hoff PM. Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience. Cancer Investig. 2002;20:3-10.
• Heo YS, Chang HM, Kim TW, Ryu MH, Ahn JH, Kim SB, et al. Hand-foot syndrome in patients treated with capecitabine-containing combination chemotherapy. J Clin Pharmacol. 2004;44:1166-72.
• Marse H, Van Cutsem E, Grothey A, Valverde S. Management of adverse events and other practical considerations in patients receiving capecitabine (Xeloda). Eur J Oncol Nurs. 2004;8(Suppl 1):S16-30.

Terms in the title (9)： 転移乳癌 ,  カペシタビン ,  療法 ,  手足症候群 ,  予防 ,  ピリドキシン ,  評価 ,  ランダム化 ,  第II相試験