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J-GLOBAL ID：201802266164900842   Reference number：18A0081653

Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion

グルタミン酸デヒドロゲナーゼ2活性を介してアンモニアからのグルタミン酸産生はグルタミン枯渇下での癌細胞増殖を支持する【Powered by NICT】

Author (6)： Takeuchi Yukiko (The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan) ,  Nakayama Yasumune (Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Nakayama Yasumune (Department of Applied Microbial Technology, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan) ,  Fukusaki Eiichiro (Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Irino Yasuhiro (The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan) ,  Irino Yasuhiro (Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 495  Issue： 1  Page： 761-767  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Cancer cells rapidly consume g...

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Thesaurus term： *Cell Proliferation ,  exponential function ,  medium ,  high speed ,  dissimilation ,  *tumor cell ,  *Ammonia ,  Carbon ,  *Glutamate Dehydrogenase ,  metabolite ,  Cell Count ,  nitrogen source ,  aliphatic ketone ,  aliphatic carboxylic acid ,  keto acid ,  dicarboxylic acid ,  amino acid ,  aliphatic amine ,  primary amine ,  carboxamide

Author keywords (5)： Ammonia ,  Cancer ,  Glutamate ,  Glutamate dehydrogenase ,  Proliferation

JST classification (4)： Cell physiology in general  (EF02010S) ,  Metabolism in general  (EB03050F) ,  Receptors on cell membrane  (EF04030C) ,  Biological function  (EB03040U)

Substance index (3)： α-Ketoglutaric acid ,  Glutamic acid ,  Glutamine

Terms in the title (9)： グルタミン酸デヒドロゲナーゼ ,  活性 ,  アンモニア ,  グルタミン酸 ,  グルタミン ,  枯渇 ,  癌細胞 ,  増殖 ,  支持