Art

J-GLOBAL ID：201802267653315218   Reference number：18A1493632

Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy

トリカプリンはトリグリセリド沈着心臓血管症のマウスモデルにおける心筋異常を治癒する

Author (15)： Suzuki Akira (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Yamaguchi Satoshi (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Li Ming (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Hara Yasuhiro (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Miyauchi Hideyuki (Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine) ,  Ikeda Yoshihiko (Department of Pathology, National Cerebral and Cardiovascular Center) ,  Zhang Bo (Department of Biochemistry, Fukuoka University Medical School) ,  Higashi Masahiro (Department of Radiology, Osaka National Hospital) ,  Ikeda Yasuyuki (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Takagi Atsuko (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Nagasaka Hironori (Department of Pediatrics, Takarazuka City Hospital) ,  Kobayashi Kunihisa (Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital) ,  Magata Yasuhiro (Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine) ,  Aoyama Toshiaki (Daitocacao Co.,LTD.) ,  Hirano Ken-ichi (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University)
Material： Journal of Oleo Science  (J Oleo Sci)
Volume： 67  Issue： 8  Page： 983-989(J-STAGE)  Publication year： 2018 
JST Material Number： G0238A  ISSN： 1345-8957  CODEN： JOSOAP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cardiovascular disease ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (6)： adipose triglyceride lipase ,  capric acid ,  iodine-123-β-methyl iodophenyl-pentadecanoic acid ,  medium-chain triglyceride ,  tricaprin ,  triglyceride deposit cardiomyovasculopathy

JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (1)： Tricaprin

Reference (32)：

• 1) Hirano, K.; Ikeda, Y.; Zaima, N.; Sakata, Y.; Matsumiya, G. Triglyceride deposit cardiomyovasculopathy. N. Engl. J. Med. 359, 2396-2398 (2008).
• 2) Hirano, K.; Ikeda, Y.; Sugimura, K.; Sakata, Y. Cardiomyocyte steatosis and defective washout of iodine-123-beta-methyl iodophenyl-pentadecanoic acid in genetic deficiency of adipose triglyceride lipase. Eur. Heart J. 36, 580 (2015).
• 3) Ikeda, Y.; Hirano, K.; Fukushima, N.; Sawa, Y. A novel type of human spontaneous coronary atherosclerosis with triglyceride deposition. Eur. Heart J. 35, 875 (2014).
• 4) Zimmermann, R.; Strauss, J.G.; Haemmerle, G.; Schoiswohl, G.; Birner-Gruenberger, R.; Riederer, M.; Lass, A.; Neuberger, G.; Eisenhaber, F.; Hermetter, A.; Zechner, R. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306, 1383-1386 (2004).
• 5) Haemmerle, G.; Lass, A.; Zimmermann, R.; Gorkiewicz, G.; Meyer, C.; Rozman, J.; Heldmaier, G.; Maier, R.; Theussl, C.; Eder, S.; Kratky, D.; Wagner, E.F.; Klingenspor, M.; Hoefler, G.; Zechner, R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312, 734-737 (2006).

Terms in the title (6)： トリカプリン ,  トリグリセリド ,  沈着 ,  マウスモデル ,  心筋 ,  治癒