Art

J-GLOBAL ID：201802275832650696   Reference number：18A1850819

Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice

慢性圧負荷はマウスにおいてSGLT1およびIL-18遺伝子発現の増加を介し心肥大および線維症を誘導する

Author (13)： Matsushita Naoko (Division of Cardiology, Department of Internal Medicine, Iwate Medical University School of Medicine) ,  Ishida Nanae (Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences) ,  Ibi Miho (Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences) ,  Saito Maki (Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences) ,  Sanbe Atsushi (Department of Pharmacotherapy, Iwate Medical University School of Pharmaceutical Sciences) ,  Shimojo Hisashi (Department of Pathology, Shinshu University School of Medicine) ,  Suzuki Satoshi (Department of Cardiology and Hematology, Fukushima Medical University) ,  Koepsell Hermann (Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Wuerzburg) ,  Takeishi Yasuchika (Department of Cardiology and Hematology, Fukushima Medical University) ,  Morino Yoshihiro (Division of Cardiology, Department of Internal Medicine, Iwate Medical University School of Medicine) ,  Taira Eiichi (Department of Pharmacology, Iwate Medical University School of Medicine) ,  Sawa Yohei (Division of Cardiology, Department of Internal Medicine, Iwate Medical University School of Medicine) ,  Hirose Masamichi (Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences)
Material： International Heart Journal (Web)
Volume： 59  Issue： 5  Page： 1123-1133(J-STAGE)  Publication year： 2018 
JST Material Number： U1357A  ISSN： 1349-3299  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *load ,...
Semi thesaurus term： *慢性圧負荷 ,...

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Author keywords (2)： Hypertension ,  Cardiomyopathy

JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Reference (39)：

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• 3. Rockman HA, Wachhorst SP, Mao L, Ross J Jr. ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. Am J Physiol 1994; 266: H2468-75.
• 4. Katanasaka Y, Suzuki H, Sunagawa Y, Hasegawa K, Morimoto T. Regulation of cardiac transcription factor GATA4 by post-translational modification in cardiomyocyte hypertrophy and heart failure. Int Heart J 2016; 57: 672-5.
• 5. Niizeki T, Takeishi Y, Kitahara T, et al. Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha (q) signaling cascade. Am J Physiol Heart Circ Physiol 2008; 295: H245-55.

Terms in the title (9)： 慢性 ,  圧負荷 ,  マウス ,  SGLT1 ,  IL-18 ,  遺伝子発現 ,  心肥大 ,  線維症 ,  誘導