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J-GLOBAL ID：201802283000890582   Reference number：18A0135780

Hypersensitivity of mouse embryonic fibroblast cells defective for DNA polymerases η, ι and κ to various genotoxic compounds: Its potential for application in chemical genotoxic screening

η,ιおよびκDNAポリメラーゼの欠損した種々の遺伝毒性化合物へのマウス胚性線維芽細胞の過敏性:化学的遺伝毒性スクリーニングへの応用のためのそのポテンシャル【Powered by NICT】

Author (9)： Akagi Jun-ichi (Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Yokoi Masayuki (Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan) ,  Yokoi Masayuki (Biosignal Research Center, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo Prefecture 657-8501, Japan) ,  Cho Young-Man (Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Toyoda Takeshi (Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Ohmori Haruo (Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan) ,  Hanaoka Fumio (Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan) ,  Hanaoka Fumio (Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki Prefecture 305-8577, Japan) ,  Ogawa Kumiko (Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan)
Material： DNA Repair
Volume： 61  Page： 76-85  Publication year： 2018 
JST Material Number： W1339A  ISSN： 1568-7864  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Genotoxic agents cause modific...

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Thesaurus term： *DNA polymerase ,  Ubiquitination ,  nucleotide ,  *genetic toxicity ,  Point Mutation ,  *DNA ,  wild type ,  knockout mouse ,  *screening (inspection) ,  DNA double strand break ,  high sensitivity ,  Alkylation ,  replicating fork ,  *MEF cell ,  laboratory animal ,  Mus musculus ,  aliphatic compound ,  sulfonate

JST classification (1)： Molecular genetics in general  (EC02010J)

Substance index (1)： Methanesulfonic acid methyl

Terms in the title (9)： DNAポリメラーゼ ,  欠損 ,  遺伝毒性 ,  マウス胚性線維芽細胞 ,  過敏性 ,  化学 ,  スクリーニング ,  応用 ,  ポテンシャル