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J-GLOBAL ID：201802283364579722   Reference number：18A0132180

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)

自己免疫調節因子(AIRE)の発現増強を介して多発性筋炎様自己免疫の逆説的開発【Powered by NICT】

Author (21)： Nishijima Hitoshi (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Kajimoto Tatsuya (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Matsuoka Yoshiki (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Mouri Yasuhiro (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Morimoto Junko (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Matsumoto Minoru (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Matsumoto Minoru (Department of Molecular and Environmental Pathology, Institute of Biomedical Sciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan) ,  Kawano Hiroshi (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Kawano Hiroshi (Department of Respiratory Medicine and Rheumatology, Institute of Biomedical Sciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan) ,  Nishioka Yasuhiko (Department of Respiratory Medicine and Rheumatology, Institute of Biomedical Sciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan) ,  Uehara Hisanori (Department of Molecular and Environmental Pathology, Institute of Biomedical Sciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan) ,  Izumi Keisuke (Department of Molecular and Environmental Pathology, Institute of Biomedical Sciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan) ,  Tsuneyama Koichi (Department of Molecular and Environmental Pathology, Institute of Biomedical Sciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan) ,  Okazaki Il-mi (Division of Immune Regulation, Institute for Genome Research, Tokushima University, Tokushima 770-8503, Japan) ,  Okazaki Taku (Division of Immune Regulation, Institute for Genome Research, Tokushima University, Tokushima 770-8503, Japan) ,  Hosomichi Kazuyoshi (Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-0934, Japan) ,  Shiraki Ayako (Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan) ,  Shibutani Makoto (Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan) ,  Mitsumori Kunitoshi (Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan) ,  Matsumoto Mitsuru (Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan) ,  Matsumoto Mitsuru (AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan)
Material： Journal of Autoimmunity  (J Autoimmun)
Volume： 86  Page： 75-92  Publication year： 2018 
JST Material Number： T0754A  ISSN： 0896-8411  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Autoimmunity is prevented by t...

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Thesaurus term： immunological tolerance ,  antigen ,  regulatory T cell ,  antigen presentation cell ,  human ,  *Autoimmunity ,  Thymus Gland ,  Peripheral Tolerance ,  Central Tolerance ,  co-stimulation molecules ,  autoreactive T-cell ,  NOD mice ,  thymic medullary epithelial cell ,  *AIRE Protein ,  reaction ,  immune response ,  suppression and control
Semi thesaurus term： 自己免疫性1型糖尿病 ,  *AIRE蛋白質 , 【Automatic Indexing@JST】

Author keywords (4)： Medullary thymic epithelial cell (mTEC) ,  AIRE ,  Muscle ,  Tolerance

JST classification (1)： Immunological reaction in general  (ED03010T)

Terms in the title (8)： 自己免疫調節因子 ,  AIRE ,  発現 ,  増強 ,  多発性筋炎 ,  自己免疫 ,  逆説 ,  開発