Art

J-GLOBAL ID：201802284571466782   Reference number：18A0363273

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

正常な上皮細胞との細胞競合は代謝変化を通して形質転換細胞の頂端伸長を促進する

Author (40)： KON Shunsuke (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  ISHIBASHI Kojiro (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  KATOH Hiroto (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  KITAMOTO Sho (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  SHIRAI Takanobu (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  TANAKA Shinya (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  KAJITA Mihoko (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  ISHIKAWA Susumu (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  YAMAUCHI Hajime (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  YAKO Yuta (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  KAMASAKI Tomoko (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  MATSUMOTO Tomohiro (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  WATANABE Hirotaka (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  EGAMI Riku (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  SASAKI Ayana (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  NISHIKAWA Atsuko (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  KAMEDA Ikumi (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  MARUYAMA Takeshi (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  NARUMI Rika (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  MORITA Tomoko (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN) ,  SASAKI Yoshiteru (Kyoto Univ., Kyoto, JPN) ,  ENOKI Ryosuke (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  ENOKI Ryosuke (JST-PRESTO, Saitama, JPN) ,  HONMA Sato (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  IMAMURA Hiromi (Kyoto Univ., Kyoto, JPN) ,  OSHIMA Masanobu (Kanazawa Univ., Kanazawa, JPN) ,  SOGA Tomoyoshi (Keio Univ., Tsuruoka, JPN) ,  MIYAZAKI Jun-ichi (Osaka Univ. Medical School, Osaka, JPN) ,  DUCHEN Michael R. (Univ. Coll. London, London, GBR) ,  NAM Jin-Min (Hokkaido Univ., Sapporo, JPN) ,  ONODERA Yasuhito (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  YOSHIOKA Shingo (Osaka Univ., Osaka, JPN) ,  KIKUTA Junichi (Osaka Univ., Osaka, JPN) ,  ISHII Masaru (Osaka Univ., Osaka, JPN) ,  IMAJO Masamichi (Kyoto Univ., Kyoto, JPN) ,  NISHIDA Eisuke (Kyoto Univ., Kyoto, JPN) ,  FUJIOKA Yoichiro (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  OHBA Yusuke (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  SATO Toshiro (Keio Univ. School of Medicine, Tokyo, JPN) ,  FUJITA Yasuyuki (Hokkaido Univ. Graduate School of Chemical Sci. and Engineering, Sapporo, JPN)
Material： Nature Cell Biology  (Nat Cell Biol)
Volume： 19  Issue： 5  Page： 530-541  Publication year： May. 2017 
JST Material Number： W1369A  ISSN： 1465-7392  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *epithelial cell ,  *neoplastic cell transformation ,  serine-threonine kinase ,  Up-Regulation ,  actin binding protein ,  *metabolic regulation ,  epithelium ,  competition ,  Carcinogenesis ,  ras gene ,  MDCK cell ,  *Warburg effect ,  pyruvate dehydrogenase kinase 4 ,  Filamins ,  Gut epithelium ,  *differentiation (biology) ,  *developmental physiology ,  membrane and film ,  histomembrane
Semi thesaurus term： PDK4

JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Cell physiology in general  (EF02010S)

Terms in the title (5)： 上皮細胞 ,  細胞競合 ,  代謝 ,  形質転換細胞 ,  促進