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J-GLOBAL ID：201802285458249793   Reference number：18A1712970

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

自閉症スペクトラム障害と統合失調症におけるコピー数変動の比較分析は,重複と生物学的洞察を明らかにする【JST・京大機械翻訳】

Author (93)： Kushima Itaru (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Kushima Itaru (Institute for Advanced Research, Nagoya University, Nagoya, Aichi 464-8601, Japan) ,  Aleksic Branko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Nakatochi Masahiro (Division of Data Science, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan) ,  Shimamura Teppei (Division of Systems Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Okada Takashi (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Uno Yota (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Uno Yota (Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA) ,  Morikawa Mako (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Ishizuka Kanako (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Shiino Tomoko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Shiino Tomoko (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan) ,  Kimura Hiroki (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Arioka Yuko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Arioka Yuko (Institute for Advanced Research, Nagoya University, Nagoya, Aichi 464-8601, Japan) ,  Arioka Yuko (Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan) ,  Yoshimi Akira (Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, Nagoya, Aichi 468-8503, Japan) ,  Takasaki Yuto (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Yu Yanjie (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Nakamura Yukako (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Yamamoto Maeri (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Iidaka Tetsuya (Department of Physical and Occupational Therapy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673, Japan) ,  Iritani Shuji (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Inada Toshiya (Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Ogawa Nanayo (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Shishido Emiko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Torii Youta (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Torii Youta (Center for Postgraduate Clinical Training and Career Development, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan) ,  Kawano Naoko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Kawano Naoko (Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi 464-8601, Japan) ,  Omura Yutaka (Aichi Psychiatric Medical Center, Nagoya, Aichi 464-0031, Japan) ,  Yoshikawa Toru (Department of Child Psychiatry, Aichi Prefectural Colony Central Hospital, Kasugai, Aichi 480-0392, Japan) ,  Uchiyama Tokio (Department of Clinical Psychology, Taisho University, Tokyo 170-8470, Japan) ,  Yamamoto Toshimichi (Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Ikeda Masashi (Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan) ,  Hashimoto Ryota (Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hashimoto Ryota (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan) ,  Hashimoto Ryota (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan) ,  Yamamori Hidenaga (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan) ,  Yasuda Yuka (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan) ,  Someya Toshiyuki (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Watanabe Yuichiro (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Egawa Jun (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Nunokawa Ayako (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Itokawa Masanari (Center for Medical Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Arai Makoto (Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Miyashita Mitsuhiro (Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Kobori Akiko (Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Suzuki Michio (Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930-0194, Japan) ,  Takahashi Tsutomu (Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930-0194, Japan) ,  Usami Masahide (Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan) ,  Kodaira Masaki (Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan) ,  Watanabe Kyota (Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan) ,  Sasaki Tsukasa (Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo 113-0033, Japan) ,  Kuwabara Hitoshi (Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan) ,  Tochigi Mamoru (Department of Neuropsychiatry, Teikyo University School of Medicine, Tokyo 173-8605, Japan) ,  Nishimura Fumichika (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Yamasue Hidenori (Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan) ,  Eriguchi Yosuke (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Benner Seico (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kojima Masaki (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Yassin Walid (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Munesue Toshio (Research Center for Child Mental Development, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan) ,  Yokoyama Shigeru (Research Center for Child Mental Development, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan) ,  Kimura Ryo (Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Funabiki Yasuko (Department of Cognitive and Behavioral Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan) ,  Kosaka Hirotaka (Research Center for Child Mental Development University of Fukui, Eiheiji, Fukui 910-1193, Japan) ,  Kosaka Hirotaka (Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui 910-1193, Japan) ,  Ishitobi Makoto (Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui 910-1193, Japan) ,  Ishitobi Makoto (Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan) ,  Ohmori Tetsuro (Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan) ,  Numata Shusuke (Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan) ,  Yoshikawa Takeo (Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Toyota Tomoko (Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Yamakawa Kazuhiro (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Suzuki Toshimitsu (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Inoue Yushi (National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, Shizuoka 420-8688, Japan) ,  Nakaoka Kentaro (Aichi Psychiatric Medical Center, Nagoya, Aichi 464-0031, Japan) ,  Goto Yu-ichi (Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan) ,  Inagaki Masumi (Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan) ,  Hashimoto Naoki (Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Sapporo 060-8638, Japan) ,  Kusumi Ichiro (Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Sapporo 060-8638, Japan) ,  Son Shuraku (Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Murai Toshiya (Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Ikegame Tempei (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Okada Naohiro (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kasai Kiyoto (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kasai Kiyoto (The International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study (UTIAS), Tokyo 113-0033, Japan) ,  Kunimoto Shohko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Mori Daisuke (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Mori Daisuke (Brain and Mind Research Center, Nagoya University, Nagoya, Aichi 466-8550, Japan) ,  Iwata Nakao (Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan) ,  Ozaki Norio (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan)
Material： Cell Reports
Volume： 24  Issue： 11  Page： 2838-2856  Publication year： 2018 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Compelling evidence in Caucasi...

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Thesaurus term： *copy number ,  completeness ,  gene ,  genome ,  phenotype ,  lipid metabolism ,  oxidative stress ,  *schizophrenia ,  intelligence disorder ,  heredity ,  pathogenesis
Semi thesaurus term： バイオインフォマティクス ,  日本人 ,  白人 ,  *自閉症スペクトラム障害 , 【Automatic Indexing@JST】

Author keywords (10)： autism spectrum disorder ,  schizophrenia ,  copy-number variation ,  array comparative genomic hybridization ,  genetic overlap ,  Japanese population ,  oxidative stress response ,  genome integrity ,  lipid metabolism ,  gene ontology

JST classification (2)： Genetic variation  (EC01030Y) ,  Molecular genetics in general  (EC02010J)

Terms in the title (6)： 自閉症スペクトラム障害 ,  統合失調症 ,  コピー数 ,  比較分析 ,  生物学 ,  洞察