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J-GLOBAL ID：201802287343646239   Reference number：18A0464792

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma

神経膠芽腫における新規融合遺伝子H MGA2EGFRの同定【Powered by NICT】

Author (20)： Komuro Akiyoshi (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Komuro Akiyoshi (Department of Biochemistry, Kindai University Faculty of Medicine, Osaka, Japan) ,  Raja Erna (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Iwata Caname (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Soda Manabu (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Isogaya Kazunobu (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Yuki Keiko (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Ino Yasushi (Division of Innovative Cancer Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Morikawa Masato (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Todo Tomoki (Division of Innovative Cancer Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Aburatani Hiroyuki (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Suzuki Hiromichi (Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan) ,  Ranjit Melissa (Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan) ,  Natsume Atsushi (Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan) ,  Mukasa Akitake (Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Saito Nobuhito (Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Okada Hitoshi (Department of Biochemistry, Kindai University Faculty of Medicine, Osaka, Japan) ,  Mano Hiroyuki (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Miyazono Kohei (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Koinuma Daizo (Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)
Material： International Journal of Cancer  (IJC)
Volume： 142  Issue： 8  Page： 1627-1639  Publication year： 2018 
JST Material Number： A0267B  ISSN： 0020-7136  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Glioblastoma is one of the mos...

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Thesaurus term： tumorigenesis ,  cell culture ,  Proteins ,  *glioblastoma ,  Gene Amplification ,  Gene Fusion ,  molecular target therapy ,  human ,  phosphorylation ,  EGF receptor ,  Protein Kinase Inhibitors ,  Cell Line ,  EGFR gene ,  *fused gene ,  molecular genetic phenomenon ,  Technology ,  operation (processing) ,  genetic technique ,  gene manipulation ,  fusion ,  DNA recombination ,  enzyme inhibitor

Author keywords (5)： fusion gene ,  HMGA2 ,  EGFR ,  STAT5 ,  erlotinib

JST classification (1)： Tumors(=neoplasms)of nervous system  (GN04000V)

Substance index (1)： Erlotinib

Terms in the title (3)： 神経膠芽腫 ,  融合遺伝子 ,  同定