Art

J-GLOBAL ID：201802291114313721   Reference number：18A1684530

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

5-ヒドロキシオキシンドール誘導体はp38-Nrf2シグナル伝達軸を活性化することによりLPS誘導炎症反応を減弱する【JST・京大機械翻訳】

Author (7)： Niino Tomomi (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Tago Kenji (Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken 329-0498, Japan) ,  Yasuda Daisuke (Division of Medicinal Chemistry and Bio-organic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Takahashi Kyoko (Division of Medicinal Chemistry and Bio-organic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Mashino Tadahiko (Division of Medicinal Chemistry and Bio-organic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Tamura Hiroomi (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Funakoshi-Tago Megumi (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan)
Material： Biochemical Pharmacology  (Biochem Pharmacol)
Volume： 155  Page： 182-197  Publication year： 2018 
JST Material Number： B0128A  ISSN： 0006-2952  CODEN： BCPCA6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： 5-Hydroxyoxindole is a urinary...

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Thesaurus term： TNF alpha ,  serum ,  anti-inflammatory action ,  ubiquitination ,  metabolite ,  *cellular signal transduction ,  interleukin 6 ,  transcription factor ,  complex(substance) ,  *inflammation
Semi thesaurus term： mRNA発現 ,  抗酸化剤 ,  Keap1蛋白質 ,  *NFE2関連因子2 ,  *P38 , 【Automatic Indexing@JST】

Author keywords (5)： 5-Hydroxyoxindole derivative ,  LPS ,  Nrf2 ,  Keap1 ,  Anti-inflammatory activity

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Terms in the title (9)： 誘導体 ,  P38 ,  NRF2 ,  シグナル伝達 ,  活性化 ,  LPS ,  誘導 ,  炎症反応 ,  減弱