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J-GLOBAL ID：201902211874697231   Reference number：19A1547676

New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines

2つの新規変異マウス系統により曝露されたmGluR1スプライス変異体の発現と輸送に関する新しい特徴【JST・京大機械翻訳】

Author (14)： Naito Rika (Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Naito Rika (Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria) ,  Kassai Hidetoshi (Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kassai Hidetoshi (Division of Molecular Genetics, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Sakai Yusuke (Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Schonherr Sabine (Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria) ,  Fukaya Masahiro (Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan) ,  Schwarzer Christoph (Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria) ,  Sakagami Hiroyuki (Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan) ,  Nakao Kazuki (Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Nakao Kazuki (Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan) ,  Aiba Atsu (Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Aiba Atsu (Division of Molecular Genetics, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Ferraguti Francesco (Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria)
Material： Frontiers in Molecular Neuroscience (Web)
Volume： 11  Page： 439  Publication year： 2018 
JST Material Number： U7082A  ISSN： 1662-5099  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Metabotropic glutamate recepto...

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Thesaurus term： binding site ,  Cell Membrane ,  clustering ,  interaction ,  Cerebellum ,  Point Mutation ,  adaptor protein ,  Phenotype ,  *synapse ,  intracellular localization ,  C-terminal side ,  isoform ,  *mGluR1 ,  Organelles ,  Endomembrane system ,  modification ,  Brain ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  primary amine
Semi thesaurus term： cell organelle , 【Automatic Indexing@JST】

Author keywords (6)： cerebellum ,  G protein-coupled receptor ,  CRISPR/Cas9 ,  electron microscopy ,  glutamate ,  trafficking

JST classification (2)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U)

Substance index (1)： Glutamic acid

Reference (46)：

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• Baude A., Nusser Z., Roberts J. D., Mulvihill E., McIlhinney R. A., Somogyi P. (1993). The metabotropic glutamate receptor (mGluR1 α) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11, 771-787. doi: 10.1016/0896-6273(93)90086-7
• Bernard V., Décossas M., Liste I., Bloch B. (2006). Intraneuronal trafficking of G-protein-coupled receptors in vivo. Trends Neurosci. 29, 140-147. doi: 10.1016/j.tins.2006.01.006
• Berthele A., Laurie D. J., Platzer S., Zieglgänsberger W., Tölle T. R., Sommer B. (1998). Differential expression of rat and human type I metabotropic glutamate receptor splice variant messenger RNAs. Neuroscience 85, 733-749. doi: 10.1016/s0306-4522(97)00670-2

Terms in the title (7)： 変異マウス ,  系統 ,  曝露 ,  mGluR1 ,  スプライス変異体 ,  発現 ,  輸送