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J-GLOBAL ID：201902215127696615   Reference number：19A1312524

Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats

PHDフィンガー蛋白質24(PHF24)ヌルラットにおける発作感受性,情動障害および認知障害の増加【JST・京大機械翻訳】

Author (20)： Serikawa Tadao (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Serikawa Tadao (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan) ,  Kunisawa Naofumi (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan) ,  Shimizu Saki (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan) ,  Kato Masaki (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan) ,  Alves Iha Higor (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan) ,  Kinboshi Masato (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan) ,  Nishikawa Hisao (KAC Co. Ltd., Kyoto 604-8423, Japan) ,  Shirakawa Yu (KAC Co. Ltd., Kyoto 604-8423, Japan) ,  Voigt Birger (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Nakanishi Satoshi (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Kuramoto Takashi (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Kuramoto Takashi (Department of Animal Science, Tokyo University of Agriculture, Kanagawa 243-0034, Japan) ,  Kaneko Takehito (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Kaneko Takehito (Department of Chemistry and Biological Sciences, Fuculty of Science and Engineering, Iwate University, Iwate 020-8551, Japan) ,  Yamamoto Takashi (Department of Molecular Genetics, Graduate School of Mathematical and Life Sciences, Hiroshima University, Hiroshima 739-8526, Japan) ,  Mashimo Tomoji (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Mashimo Tomoji (Genome Editing Research and Development Center, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan) ,  Sasa Masashi (Nagisa Clinic, Osaka 573-1183, Japan) ,  Ohno Yukihiro (Department of Pharmacology, Osaka University of Pharmacological Sciences, Osaka 569-1094, Japan)
Material： Behavioural Brain Research  (Behav Brain Res)
Volume： 369  Page： Null  Publication year： 2019 
JST Material Number： A1150A  ISSN： 0166-4328  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Phf24 is known as Gαi-interact...

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Thesaurus term： *sensitivity ,  Phenotype ,  kindling ,  spontaneous behavior ,  *emotional disturbance ,  *seizure (disease) ,  convulsion ,  *Proteins ,  interaction ,  age in week ,  dark period ,  cognition function ,  GTP-Binding Protein alpha Subunits ,  *Cognition Disorders ,  nitrogen heterocyclic compound ,  lactone ,  imidazole alkaloid

Author keywords (6)： Cognition ,  Emotional behavior ,  Epileptogenesis ,  GABA_B receptor ,  GINIP ,  Phf24

JST classification (2)： Central nervous system  (EJ12030F) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Pilocarpine

Terms in the title (5)： 蛋白質 ,  発作 ,  感受性 ,  情動障害 ,  認知障害