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J-GLOBAL ID：201902218075271652   Reference number：19A1696407

Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins

ATP結合カセット輸送体蛋白質における立体構造シフトと疾患関連変異部位との関係

Author (5)： Sakamoto Mika (Graduate School of Humanities and Sciences, Ochanomizu University) ,  Suzuki Hirofumi (School of Advanced Science and Engineering, Waseda University) ,  Yura Kei (Graduate School of Humanities and Sciences, Ochanomizu University) ,  Yura Kei (School of Advanced Science and Engineering, Waseda University) ,  Yura Kei (Center for Simulation Science and Informational Biology, Ochanomizu University)
Material： Biophysics and Physicobiology (Web)  (Biophys Physicobiology (Web))
Volume： 16  Page： 68-79(J-STAGE)  Publication year： 2019 
JST Material Number： U0030A  ISSN： 2189-4779  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *ABC transporter ,...
Semi thesaurus term： *conformational analysis ,...

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Author keywords (5)： coupling helix ,  differential map ,  pathogenic variation ,  pivot-like residue ,  protein 3D structure

JST classification (2)： Molecular structure  (EB03020Y) ,  Congenital diseases,deformities in general.  (GD03010V)

Reference (41)：

• [1] Alberts, B., Johnson A., Lewis, J., Morgan, D., Raff, M., Roberts, K., et al. Molecular Biology of The Cell, Sixth Edition (Garland Science, New York, 2015).
• [2] Vasiliou, V., Vasiliou, K. & Nebert, D. W. Human ATP-binding cassette (ABC) transporter family. Human Genomics 3, 281-290 (2009).
• [3] Gouaux, E. & Mackinnon, R. Principles of selective ion transport in channels and pumps. Science 310, 1461-1465 (2005).
• [4] Schlessinger, A., Khuri, N., Giacomini, K. M. & Sali, A. Molecular modeling and ligand docking for Solute Carrier (SLC) transporters. Curr. Top. Med. Chem. 13, 843-856 (2013).
• [5] Tanaka, K. J., Song, S., Mason, K. & Pinkett, H. W. Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis. Biochim. Biophys. Acta S0005-2736, 30261-30264 (2017).

Terms in the title (6)： ATP結合カセット輸送体 ,  蛋白質 ,  立体構造 ,  シフト ,  疾患 ,  変異