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J-GLOBAL ID：201902221501693072   Reference number：19A1492160

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

LRRK2とその基質Rab GTPアーゼはストレスを受けたリソソームに連続的に標的化され,それらのホメオスタシスを維持する【JST・京大機械翻訳】

Author (11)： Eguchi Tomoya (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Kuwahara Tomoki (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Sakurai Maria (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Komori Tadayuki (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Fujimoto Tetta (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Ito Genta (Laboratory of Brain and Neurological Disorders, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Yoshimura Shin-ichiro (Department of Cell Biology, Graduate School of Medicine, Osaka University, 565-0871 Osaka, Japan) ,  Harada Akihiro (Department of Cell Biology, Graduate School of Medicine, Osaka University, 565-0871 Osaka, Japan) ,  Fukuda Mitsunori (Laboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, 980-8578 Sendai, Japan) ,  Koike Masato (Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Iwatsubo Takeshi (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 39  Page： E9115-E9124  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Leucine-rich repeat kinase 2 (...

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Thesaurus term： effector ,  *substrate (biochemistry) ,  *homeostasis ,  *GTPase ,  screening (inspection) ,  *targeting ,  vacuole ,  phosphorylation ,  animal ,  *lysosome ,  secretion (physiology) ,  Rab8 protein ,  *rab GTP-Binding Proteins ,  *leucine rich repeat kinase 2 ,  aliphatic amine ,  aliphatic carboxylic acid ,  branched-chain amino acid

Author keywords (4)： LRRK2 ,  lysosome ,  Rab GTPase ,  phosphorylation

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (1)： Leucine

Terms in the title (8)： LRRK2 ,  基質 ,  Rab ,  GTPアーゼ ,  ストレス ,  リソソーム ,  標的化 ,  ホメオスタシス