Ubr1p-Cup9p-Ptr2p pathway involves in the sensitivity to readthrough compounds negamycin derivatives in budding yeast

HAMADA Keisuke; NAITO Akari; HAMAGUCHI Yu; KANESAKI Yu; KASAHARA Koji; TAGUCHI Akihiro; OMURA Noriko; HAYASHI Yoshio; USUI Takeo

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J-GLOBAL ID：201902221558707790 Reference number：19A2356411

Ubr1p-Cup9p-Ptr2p pathway involves in the sensitivity to readthrough compounds negamycin derivatives in budding yeast

UBR1p-Cup9p-Ptr2p経路は出芽酵母におけるリードスルー化合物ネガマイシン誘導体への感受性に関与する

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Material：
Volume： 83 Issue： 10 Page： 1889-1892 Publication year： Oct. 2019
JST Material Number： G0021A ISSN： 0916-8451 CODEN： BBBIEJ Document type： Article
Article type：短報 Country of issue： United Kingdom (GBR) Language： ENGLISH (EN)

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Transport of cell membrane , Antibiotics in general , Microorganism biochemistry

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Welch EM, Barton ER, Zhuo J, et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature. 2007;447:87-91.
Hamada M, Takeuchi T, Kondo S, et al. A new antibiotic, negamycin. J Antibiot. (Tokyo). 1970;23:170-171.
Arakawa M, Shiozuka M, Nakayama Y, et al. Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice. J Biochem. 2003;134:751-758.
Taguchi A, Hamada K, Kotake M, et al. Discovery of natural products possessing selective eukaryotic readthrough activity: 3-epi-deoxynegamycin and its leucine adduct. ChemMedChem. 2014;9:2233-2237.

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