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J-GLOBAL ID：201902221919677657   Reference number：19A2607823

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

Parkinson病関連IPLA2-Via/PLA2G6は膜リモデリングを介してニューロン機能とα-シヌクレイン安定性を調節する【JST・京大機械翻訳】

Author (30)： Mori Akio (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Hatano Taku (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Inoshita Tsuyoshi (Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Shiba-Fukushima Kahori (Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Koinuma Takahiro (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Meng Hongrui (Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Kubo Shin-ichiro (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Spratt Spencer (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Cui Changxu (Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Yamashita Chikara (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Miki Yoshimi (Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Yamamoto Kei (Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, 770-8513 Tokushima, Japan) ,  Yamamoto Kei (PRIME, Japan Agency for Medical Research and Development (AMED), 100-0004 Tokyo, Japan) ,  Hirabayashi Tetsuya (Laboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, 156-8506 Tokyo, Japan) ,  Murakami Makoto (Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Murakami Makoto (Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), AMED, 100-0004 Tokyo, Japan) ,  Takahashi Yoshikazu (Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), AMED, 100-0004 Tokyo, Japan) ,  Takahashi Yoshikazu (Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, 162-8655 Tokyo, Japan) ,  Shindou Hideo (Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), AMED, 100-0004 Tokyo, Japan) ,  Shindou Hideo (Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, 162-8655 Tokyo, Japan) ,  Shindou Hideo (Department of Lipid Science, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan) ,  Nonaka Takashi (Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 156-8506 Tokyo, Japan) ,  Hasegawa Masato (Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 156-8506 Tokyo, Japan) ,  Okuzumi Ayami (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Imai Yuzuru (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Imai Yuzuru (Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Hattori Nobutaka (Department of Neurology, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Hattori Nobutaka (Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Hattori Nobutaka (Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan) ,  Hattori Nobutaka (Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 116  Issue： 41  Page： 20689-20699  Publication year： 2019 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Mutations in the iPLA2-VIA/PLA...

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Thesaurus term： *neuron ,  wild type ,  neural transmission ,  aggregation ,  protein ,  mitochondria ,  Drosophila ,  variation(biology) ,  phenotype ,  gene ,  human(primates) ,  unsaturated fatty acid ,  diene
Semi thesaurus term： 神経変性 ,  *α-シヌクレイン ,  *リモデリング , 【Automatic Indexing@JST】

Author keywords (5)： Parkinson’s disease ,  lipids ,  Drosophila ,  ER stress ,  α-synuclein

JST classification (3)： Transport of cell membrane  (EF04020R) ,  Biological function  (EB03040U) ,  Biomembrane in general  (EF04010G)

Substance index (1)： Linolic acid

Terms in the title (6)： Parkinson病 ,  リモデリング ,  ニューロン ,  α-シヌクレイン ,  安定性 ,  調節