Art

J-GLOBAL ID：201902230711711699   Reference number：19A2294681

Isotope Corrected Chiral and Achiral Nontargeted Metabolomics: An Approach for High Accuracy and Precision Metabolomics Based on Derivatization and Its Application to Cerebrospinal Fluid of Patients with Alzheimer’s Disease

同位体補正カイラル及びアキラル非標的メタボロミクス:誘導体化に基づく高精度及び精密メタボロミクスのためのアプローチ及びAlzheimer病患者の脳脊髄液への応用【JST・京大機械翻訳】

Author (7)： Takayama Takahiro (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan) ,  Mizuno Hajime (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan) ,  Toyo'oka Toshimasa (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan) ,  Akatsu Hiroyasu (Department of Medicine for Aging Place, Community Health Care/Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Japan) ,  Akatsu Hiroyasu (Department of Neuropathology, Choju Medical Institute, Fukushimura Hospital, Japan) ,  Inoue Koichi (Laboratory of Clinical & Analytical Chemistry, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan) ,  Todoroki Kenichiro (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan)
Material： Analytical Chemistry  (Anal Chem)
Volume： 91  Issue： 7  Page： 4396-4404  Publication year： 2019 
JST Material Number： A0395A  ISSN： 0003-2700  CODEN： ANCHAM  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： We propose a chiral metabolomi...

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Thesaurus term： mass spectrometry ,  *derivatization ,  mass spectrum ,  high-resolution ,  *isotope ,  quadrupole ,  *human ,  biomarker ,  isomer (molecule) ,  *Alzheimer Disease ,  data analysis ,  *cerebrospinal fluid ,  TOF-MS ,  *Metabolomics ,  *achiral ,  *chirality ,  *body fluid

JST classification (2)： Biosubstance in general  (EB02010G) ,  Miscellaneous analytical methods in general  (CC08010X)

Terms in the title (11)： 同位体 ,  カイラル ,  アキラル ,  標的 ,  メタボロミクス ,  誘導体化 ,  精密 ,  Alzheimer病 ,  患者 ,  脳脊髄液 ,  応用