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J-GLOBAL ID：201902240818917755   Reference number：19A0994420

Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality

マウスにおけるリジルヒドロキシラーゼ2の欠損は初期胚致死に導く全身小胞体ストレスを引き起こす【JST・京大機械翻訳】

Author (18)： Kasamatsu Atsushi (Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan) ,  Uzawa Katsuhiro (Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan) ,  Uzawa Katsuhiro (Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Hayashi Fumihiko (Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Kita Akihiro (Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan) ,  Okubo Yasuhiko (Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Saito Tomoaki (Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan) ,  Kimura Yasushi (Department of Oral and Maxillofacial Surgery Research Institute, National Defense Medical College Hospital, Saitama, Japan) ,  Miyamoto Isao (Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan) ,  Oka Noritoshi (Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Shiiba Masashi (Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Ito Chizuru (Department of Functional Anatomy, Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Toshimori Kiyotaka (Department of Functional Anatomy, Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Toshimori Kiyotaka (Future Medicine Research Center, Chiba University, Chiba, Japan) ,  Miki Takashi (Department of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Yamauchi Mitsuo (Department of Oral and Craniofacial Health Sciences, School of Dentistry, University of North Carolina at Chapel Hill, NC, USA) ,  Tanzawa Hideki (Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan) ,  Tanzawa Hideki (Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 512  Issue： 3  Page： 486-491  Publication year： 2019 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Lysyl hydroxylase 2 (LH2) is a...

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Thesaurus term： polymerase chain reaction ,  Apoptosis ,  gene ,  Up-Regulation ,  metastasis ,  enzyme ,  immunohistochemistry ,  Bax protein ,  hydroxylation ,  *Mus musculus ,  heart ventricle ,  shake out ,  knockout mouse ,  fibrous disease ,  Cas9 protein ,  *Myomorpha ,  laboratory animal
Semi thesaurus term： Cas9 , 【Automatic Indexing@JST】

Author keywords (6)： Lysyl hydroxylase 2 (LH2) ,  Embryonic lethality ,  CRISPR/Cas9-mediated genomic editing ,  Endoplasmic reticulum stress ,  Apoptosis ,  Collagen cross-linking

JST classification (1)： Heart  (EJ04020D)

Terms in the title (5)： マウス ,  欠損 ,  初期胚 ,  全身 ,  小胞体ストレス