Art

J-GLOBAL ID：201902241733992600   Reference number：19A0255689

A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b

高度に生物活性なLys欠損IFNは非修飾IFN-α2bの等価生物活性を持つ部位特異的ジPEG化IFNを誘導する【JST・京大機械翻訳】

Author (17)： Imada Takashi (Graduate School of Life Science, Tokyo Institute of Technology) ,  Moriya Koji (Graduate School of Life Science, Tokyo Institute of Technology) ,  Uchiyama Masahiko (Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology) ,  Inukai Naoto (Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology) ,  Hitotsuyanagi Mitsuhiro (Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology) ,  Masuda Akiko (RIKEN Center for Sustainable Resource Science, Japan) ,  Suzuki Takehiro (RIKEN Center for Sustainable Resource Science, Japan) ,  Ayukawa Shotaro (Department of Electrical Engineering and Bioscience, Waseda University, Japan) ,  Tagawa Yo-ichi (Graduate School of Life Science, Tokyo Institute of Technology) ,  Dohmae Naoshi (RIKEN Center for Sustainable Resource Science, Japan) ,  Kohara Michinori (Tokyo Metropolitan Institute of Medical Science, Japan) ,  Yamamura Masayuki (Graduate School of Life Science, Tokyo Institute of Technology) ,  Yamamura Masayuki (Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology) ,  Yamamura Masayuki (Graduate School of Computing, Tokyo Institute of Technology) ,  Kiga Daisuke (Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology) ,  Kiga Daisuke (Department of Electrical Engineering and Bioscience, Waseda University, Japan) ,  Kiga Daisuke (Graduate School of Computing, Tokyo Institute of Technology)
Material： ACS Synthetic Biology
Volume： 7  Issue： 11  Page： 2537-2546  Publication year： 2018 
JST Material Number： W5048A  ISSN： 2161-5063  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Although conjugation with poly...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A0255689&from=J-GLOBAL&jstjournalNo=W5048A") }}

Thesaurus term： Proteins ,  pharmacokinetics ,  interferon ,  therapy ,  in vitro experiment ,  *interferon alpha 2b ,  antiviral action ,  *biological activity ,  gene ,  directed evolution ,  *polyethylene glycolylation

Author keywords (5)： site-specific di-PEGylation ,  interferon ,  directed evolution ,  Lys-deficient proteins ,  genetic code engineering

JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antiviral drugs  (GW17040O)

Terms in the title (9)： 生物活性 ,  Lys ,  欠損 ,  IFN ,  修飾 ,  IFN-α2b ,  等価 ,  PEG化 ,  誘導