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J-GLOBAL ID：201902244778392403   Reference number：19A1067166

Protective Effect of Highly Polymeric A-Type Proanthocyanidins from Seed Shells of Japanese Horse Chestnut (Aesculus turbinata BLUME) against Light-Induced Oxidative Damage in Rat Retina

ラット網膜における光誘発酸化損傷に対する日本の馬クリ(aesculus turbata Blume)の種子殻からの高分子A型プロアントシアニジンの保護効果【JST・京大機械翻訳】

Author (7)： Ishihara Tomoe (Department of Ophthalmology, School of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan) ,  Ishihara Tomoe (Department of Research and Development, Kotobuki Seika Co., Ltd., 2028 Hatagasaki, Yonago, Tottori 683-0845, Japan) ,  Kaidzu Sachiko (Department of Ophthalmology, School of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan) ,  Kimura Hideto (Department of Research and Development, Kotobuki Seika Co., Ltd., 2028 Hatagasaki, Yonago, Tottori 683-0845, Japan) ,  Koyama Yasurou (Department of Ophthalmology, School of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan) ,  Matsuoka Yotaro (Department of Ophthalmology, School of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan) ,  Ohira Akihiro (Department of Ophthalmology, School of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan)
Material： Nutrients (Web)
Volume： 10  Issue： 5  Page： 593  Publication year： 2018 
JST Material Number： U7255A  ISSN： 2072-6643  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Retinal tissue is exposed to o...

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Thesaurus term： *rat ,  electrophoresis ,  oral administration ,  *oxidation ,  oxidative stress ,  *protective action ,  visible light ,  plasma(blood) ,  apoptosis ,  polyphenol ,  body weight ,  *retina
Semi thesaurus term： 抗酸化活性 ,  抗酸化剤 , 【Automatic Indexing@JST】

Author keywords (6)： retina protection ,  Japanese horse chestnut ,  Aesculus turbinata BLUME ,  polyphenolic compound ,  antioxidant ,  proanthocyanidin

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Proanthocyanidin

Reference (30)：

• Ogawa, S.; Kimura, H.; Niimi, A.; Katsube, T.; Jisaka, M.; Yokota, K. Fractionation and structural characterization of polyphenolic antioxidants from seed shells of Japanese horse chestnut (Aesculus turbinata BLUME). J. Agric. Food Chem. 2008, 56, 12046-12051.
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• Pennington, K.L.; DeAngelis, M.M. Epidemiology of age-related macular degeneration (AMD); associations with cardiovascular disease phenotypes and lipid factors. Eye Vis. 2016, 3, 1-20.
• Schützea, C.; Wedla, M.; Baumannb, B.; Pircherb, M.; Hitzenberger, C.K.; Schmidt-Erfurth, U. Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration. Am. J. Ophthalmol. 2015, 159, 1100-1114.
• Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol. 2001, 119, 1417-1436.

Terms in the title (13)： ラット ,  網膜 ,  誘発 ,  酸化損傷 ,  日本 ,  馬 ,  クリ ,  Aesculus ,  種子 ,  殻 ,  高分子 ,  プロアントシアニジン ,  保護効果