Art

J-GLOBAL ID：201902247225053625   Reference number：19A1550881

Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments

低酸素環境に適応させた癌細胞における選択的増殖阻害剤としての海洋天然物ジクチオセラチン-Aおよび-Cの標的同定【JST・京大機械翻訳】

Author (8)： Kawachi Takashi (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Tanaka Shun (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Fukuda Akinori (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Sumii Yuji (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Setiawan Andi (Department of Chemistry, Faculty of Science, Lampung University, J1. Prof. Dr. Sumantri Brodjonegoro No. 1, Bandar Lampung 35145, Indonesia) ,  Kotoku Naoyuki (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kobayashi Motomasa (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Arai Masayoshi (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan)
Material： Marine Drugs (Web)
Volume： 17  Issue： 3  Page： 163  Publication year： 2019 
JST Material Number： U7236A  ISSN： 1660-3397  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Hypoxia-adapted cancer cells i...

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Thesaurus term： tumor ,  protein ,  *tumor cell ,  culture(biology) ,  probe ,  antitumor action ,  complex(substance) ,  phenotype ,  *ocean ,  *oxygen deficiency ,  *inhibition of multiplication ,  *marine natural product
Semi thesaurus term： ノックダウン細胞 ,  プレフォルディン ,  標的分子 , 【Automatic Indexing@JST】

Author keywords (6)： dictyoceratin-A ,  hypoxia ,  cancer ,  RNA polymerase II-associated protein 3 ,  probe molecule ,  target molecule

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (24)：

• Dewhirst, M.W.; Cao, Y.; Moeller, B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat. Rev. Cancer 2008, 8, 425-437.
• Semenza, G.L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010, 29, 625-634.
• Han, J.M.; Lim, H.N.; Jung, H.J. Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression. Oncol. Rep. 2017, 38, 3430-3438.
• Bach, D.H.; Kim, S.H.; Hong, J.Y.; Park, H.J.; Oh, D.C.; Lee, S.K. Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1α and Induces Apoptosis in Human Colorectal Cancer Cells. Mar. Drugs 2015, 13, 6962-6976.
• Chan, S.T.; Patel, P.R.; Ransom, T.R.; Henrich, C.J.; McKee, T.C.; Goey, A.K.; Cook, K.M.; Figg, W.D.; McMahon, J.B.; Schnermann, M.J.; et al. Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α. J. Am. Chem. Soc. 2015, 137, 5569-5575.

Terms in the title (7)： 低酸素環境 ,  適応 ,  癌細胞 ,  増殖阻害剤 ,  海洋天然物 ,  標的 ,  同定