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J-GLOBAL ID：201902252190548170   Reference number：19A1347316

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis

統合失調症におけるクロザピン薬理遺伝学的研究:有効性と無顆粒球症【JST・京大機械翻訳】

Author (6)： Numata Shusuke (Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, Japan) ,  Umehara Hidehiro (Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, Japan) ,  Ohmori Tetsuro (Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, Japan) ,  Hashimoto Ryota (Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Hashimoto Ryota (Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan) ,  Hashimoto Ryota (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan)
Material： Frontiers in Pharmacology (Web)
Volume： 9  Page： 1049  Publication year： 2018 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Clozapine is an efficacious at...

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Thesaurus term： toxicity ,  *effectiveness ,  genome ,  human ,  *schizophrenia ,  *granulocytopenia ,  *Pharmacology ,  human leucocyte antigen ,  Genome-Wide Association Study ,  *Heredity ,  candidate gene ,  Atypical antipsychotic ,  *Pharmacogenetics ,  adverse reaction ,  nitrogen heterocyclic compound ,  aromatic chlorine compound ,  polynuclear aromatic compound ,  antipsychotic agent
Semi thesaurus term： 有害事象 ,  治療抵抗性統合失調症 , 【Automatic Indexing@JST】

Author keywords (8)： clozapine ,  schizophrenia ,  clinical response ,  agranulocytosis ,  pharmacogenetics ,  SNP ,  GWAS ,  review

JST classification (2)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Substance index (1)： Clozapine

Reference (135)：

• Adkins D. E., Aberg K., McClay J. L., Bukszár J., Zhao Z., Jia P., et al. (2011). Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. Mol. Psychiatry 16, 321-332. doi: 10.1038/mp.2010.14
• Alawami M., Wasywich C., Cicovic A., Kenedi C. (2014). A systematic review of clozapine induced cardiomyopathy. Int. J. Cardiol. 176, 315-320. doi: 10.1016/j.ijcard.2014.07.103
• Alvir J. M., Lieberman J. A., Safferman A. Z., Schwimmer J. L., Schaaf J. A. (1993). Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N. Engl. J. Med. 329, 162-167. doi: 10.1056/NEJM199307153290303
• Amar A., Segman R. H., Shtrussberg S., Sherman L., Safirman C., Lerer B., et al. (1998). An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. Int. J. Neuropsychopharmacol. 1, 41-44. doi: 10.1017/S1461145798001023
• Anil Yagcioglu A. E., Ilhan B. Ç., Göktaş M. T., Babaoglu M. O., Uz E., Yazici M. K. (2011). Agranulocytosis related to clozapine in monozygotic twins and association with allelic variants of multidrug resistance gene MDR1. J. Clin. Psychopharmacol. 31, 247-249. doi: 10.1097/JCP.0b013e31821084dc

Terms in the title (5)： 統合失調症 ,  クロザピン ,  薬理遺伝学 ,  研究 ,  無顆粒球症