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J-GLOBAL ID：201902252283186135   Reference number：19A1589616

Recent Progress on the Molecular Mechanism of Quality Controls Induced by Ribosome Stalling

リボソーム失速により誘導される品質管理の分子機構に関する最近の進歩【JST・京大機械翻訳】

Author (3)： Ikeuchi Ken (Gene Regulation Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan) ,  Izawa Toshiaki (Gene Regulation Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan) ,  Inada Toshifumi (Gene Regulation Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan)
Material： Frontiers in Genetics (Web)
Volume： 9  Page： 743  Publication year： 2018 
JST Material Number： U7071A  ISSN： 1664-8021  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Accurate gene expression is a ...

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Thesaurus term： mRNA ,  high speed ,  polypeptide ,  genetic regulation ,  *stall ,  protein ,  *ribosome ,  *quality control ,  necessary condition ,  homeostasis ,  gene expression ,  interaction
Semi thesaurus term： 蛋白質凝集 ,  翻訳停止 ,  *分子機構 , 【Automatic Indexing@JST】

Author keywords (5)： ribosome ,  ribosome stalling ,  no-go mRNA decay ,  ribosome-associated quality control ,  ribosome ubiquitination

JST classification (2)： Gene expression  (EC02040Q) ,  Biological function  (EB03040U)

Reference (52)：

• Bengtson M. H., Joazeiro C. A. (2010). Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467 470-473. doi: 10.1038/nature09371
• Brandman O., Hegde R. S. (2016). Ribosome-associated protein quality control. Nat. Struct. Mol. Biol. 23 7-15. doi: 10.1038/nsmb.3147
• Brandman O., Stewart-Ornstein J., Wong D., Larson A., Williams C. C., Li G. W., et al (2012). A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell 1511042-1054. doi: 10.1016/j.cell.2012.10.044
• Brickner J. R., Soll J. M., Lombardi P. M., Vagbo C. B., Mudge M. C., Oyeniran C., et al (2017). A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature 551 389-393. doi: 10.1038/nature24484
• Chen L., Muhlrad D., Hauryliuk V., Cheng Z., Lim M. K., Shyp V., et al (2010). Structure of the Dom34-Hbs1 complex and implications for no-go decay. Nat. Struct. Mol. Biol. 17 1233-1240. doi: 10.1038/nsmb.1922

Terms in the title (5)： リボソーム ,  失速 ,  誘導 ,  品質管理 ,  分子機構