Art

J-GLOBAL ID：201902255418718533   Reference number：19A0313470

The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity

腎臓トランスチレチン沈着物におけるヘパラン硫酸Sドメインの蓄積は線維形成を促進し細胞毒性を促進する【JST・京大機械翻訳】

Author (15)： Kameyama Hirokazu (Department of Molecular Physical Pharmaceutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan) ,  Uchimura Kenji (Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Uchimura Kenji (Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, Universite de Lille 1, Villeneuve d’Ascq, France) ,  Yamashita Taro (Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Kuwabara Kaori (Department of Molecular Physical Pharmaceutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan) ,  Mizuguchi Mineyuki (Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Hung Shang-Cheng (Genomics Research Center, Academia Sinica, Taipei, Taiwan) ,  Okuhira Keiichiro (Department of Molecular Physical Pharmaceutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan) ,  Masuda Tomohiro (Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kosugi Tomoki (Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Ohgita Takashi (Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Saito Hiroyuki (Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Ando Yukio (Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Nishitsuji Kazuchika (Department of Biochemistry, Wakayama Medical University, Wakayama, Japan) ,  Nishitsuji Kazuchika (Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan)
Material： American Journal of Pathology  (Am J Pathol)
Volume： 189  Issue： 2  Page： 308-319  Publication year： 2019 
JST Material Number： E0065B  ISSN： 0002-9440  CODEN： AJPAA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The highly sulfated domains of...

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Thesaurus term： sulfuric ester hydrolase ,  interaction ,  growth factor ,  *cytotoxicity ,  *Prealbumin ,  in vitro experiment ,  sulfation ,  Cellulase ,  Heparin ,  Amyloidosis ,  amyloid fiber ,  Glypicans ,  cell surface ,  *domain structure ,  *albumin ,  *serum protein ,  hematological drug ,  anticoagulant ,  drug ,  glycoside ,  polyuronide ,  glucoside ,  sugar sulfate ,  drug acting on blood and body fluid
Semi thesaurus term： リモデリング , 【Automatic Indexing@JST】

JST classification (4)： Molecular structure  (EB03020Y) ,  Congenital diseases,deformities in general.  (GD03010V) ,  Basic neurology  (GN01020W) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Terms in the title (9)： 腎臓 ,  トランスチレチン ,  沈着物 ,  ヘパラン硫酸 ,  ドメイン ,  蓄積 ,  線維形成 ,  促進 ,  細胞毒性