Art

J-GLOBAL ID：201902258831726310   Reference number：19A0873224

Modeling lethal X-linked genetic disorders in pigs with ensured fertility

保証された受精率を有するブタにおける致死性X連鎖遺伝性疾患のモデリング【JST・京大機械翻訳】

Author (24)： Matsunari Hitomi (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Watanabe Masahito (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Nakano Kazuaki (Laboratory of Developmental Engineering, Meiji University, Kawasaki 214-8571, Japan) ,  Enosawa Shin (National Center for Child Health and Development, Tokyo 157-0074, Japan) ,  Umeyama Kazuhiro (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Uchikura Ayuko (Laboratory of Developmental Engineering, Meiji University, Kawasaki 214-8571, Japan) ,  Yashima Sayaka (Laboratory of Developmental Engineering, Meiji University, Kawasaki 214-8571, Japan) ,  Fukuda Toru (Laboratory of Developmental Engineering, Meiji University, Kawasaki 214-8571, Japan) ,  Klymiuk Nikolai (Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilian University Munich, D-81377 Munich, Germany) ,  Kurome Mayuko (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Kurome Mayuko (Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilian University Munich, D-81377 Munich, Germany) ,  Kessler Barbara (Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilian University Munich, D-81377 Munich, Germany) ,  Wuensch Annegret (Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilian University Munich, D-81377 Munich, Germany) ,  Zakhartchenko Valeri (Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilian University Munich, D-81377 Munich, Germany) ,  Wolf Eckhard (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Wolf Eckhard (Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilian University Munich, D-81377 Munich, Germany) ,  Hanazono Yutaka (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi 329-0498, Japan) ,  Nagaya Masaki (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Umezawa Akihiro (National Center for Child Health and Development, Tokyo 157-0074, Japan) ,  Nakauchi Hiromitsu (Division of Stem Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan) ,  Nakauchi Hiromitsu (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305) ,  Nakauchi Hiromitsu (Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305) ,  Nagashima Hiroshi (Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan) ,  Nagashima Hiroshi (Laboratory of Developmental Engineering, Meiji University, Kawasaki 214-8571, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 4  Page： 708-713  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Genetically engineered pigs pl...

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Thesaurus term： gene manipulation ,  gene ,  *modeling ,  experimental disease ,  breeding(genetics) ,  Mutation ,  somatic cell ,  fertility (gamete) ,  Chimera ,  Phenotype ,  Reproduction ,  Genotype ,  Genetic Variation
Semi thesaurus term： variation(biology) ,  正常細胞 ,  *致死性 , 【Automatic Indexing@JST】

Author keywords (5)： blastocyst complementation ,  chimera ,  disease model pig ,  gene knockout ,  somatic cell cloning

JST classification (1)： Gene manipulation  (EC02050B)

Terms in the title (6)： 保証 ,  受精率 ,  ブタ ,  致死性 ,  遺伝性疾患 ,  モデリング