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J-GLOBAL ID：201902273371564420   Reference number：19A1249230

Derivatives of Dictyostelium Differentiation-Inducing Factors Inhibit Serum-Dependent Cell Migration of Murine Osteosarcoma LM8 Cells

Dictyosteliumの分化誘導因子誘導体はマウス骨肉腫LM8細胞の血清依存性細胞移動を阻害する

Author (5)： KUBOHARA YUZURU (Laboratory of Health and Life Science, Juntendo University Graduate School of Health and Sports Science) ,  KUBOHARA YUZURU (Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University) ,  KIKUCHI HARUHISA (Laboratory of Natural Products Chemistry, Tohoku University Graduate School of Pharmaceutical Sciences) ,  OSHIMA YOSHITERU (Laboratory of Natural Products Chemistry, Tohoku University Graduate School of Pharmaceutical Sciences) ,  OSHIMA YOSHITERU (United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine)
Material： 順天堂醫事雑誌  (Juntendo Medical Journal)
Volume： 65  Issue： 1  Page： 71-76(J-STAGE)  Publication year： 2019 
JST Material Number： G0715A  ISSN： 2187-9737  CODEN： JIZUA2  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antitumor action ,...
Semi thesaurus term： Dictyostelium discoideum ,...

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Author keywords (5)： cell migration ,  Dictyostelium discoideum ,  differentiation-inducing factor (DIF) ,  metastasis ,  osteosarcoma

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (5)： 1-(3-クロロ-2,6-ジヒドロキシ-4-メトキシフェニル)-1-ヘプタノン ,  1-(4-ブトキシ-3-クロロ-2,6-ジヒドロキシフェニル)-1-ヘキサノン ,  Br-DIF-1 ,  DIF-1 ,  DIF-3

Reference (27)：

• 1) Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G: Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev, 2006; 32: 423-436.
• 2) Marina N, Gebhardt M, Teot L, Gorlick R: Biology and therapeutic advances for pediatric osteosarcoma. Oncologist, 2004; 9: 422-441.
• 3) Morris HR, Taylor GW, Masento MS, Jermyn KA, Kay RR: Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum. Nature, 1987; 328: 811-814.
• 4) Morris HR, Masento MS, Taylor GW, Jermyn KA, Kay RR: Structure elucidation of two differentiation inducing factors (DIF-2 and DIF-3) from the cellular slime mould Dictyostelium discoideum. Biochem J, 1988; 249: 903-906.
• 5) Kay RR, Berks M, Traynor D: Morphogen hunting in Dictyostelium. Development, 1989; 107 Suppl: 81-90.

Terms in the title (10)： Dictyostelium ,  分化誘導因子 ,  誘導体 ,  マウス ,  骨肉腫 ,  LM8細胞 ,  血清 ,  依存性 ,  細胞移動 ,  阻害