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J-GLOBAL ID：201902275353669484   Reference number：19A2414990

Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure

ポリチオアミド構造を有する抗腫瘍性リボソーム合成および翻訳後修飾ペプチド,プレチオビリダミドの作用機序【JST・京大機械翻訳】

Author (19)： Takase Shohei (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Takase Shohei (School of Agriculture, Meiji University, Kanagawa, Japan) ,  Kurokawa Rumi (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Kondoh Yasumitsu (Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Honda Kaori (Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Suzuki Takehiro (Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, Japan) ,  Kawahara Teppei (Japan Biological Informatics Consortium (JBIC), Tokyo, Japan) ,  Ikeda Haruo (Kitasato Institute for Life Sciences, Kitasato University, Kanagawa, Japan) ,  Dohmae Naoshi (Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, Japan) ,  Osada Hiroyuki (Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Shin-ya Kazuo (National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan) ,  Shin-ya Kazuo (Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan) ,  Kushiro Tetsuo (School of Agriculture, Meiji University, Kanagawa, Japan) ,  Yoshida Minoru (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Yoshida Minoru (Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan) ,  Yoshida Minoru (Seed Compounds Exploratory Unit for Drug Discovery Platform, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science, Japan) ,  Yoshida Minoru (Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan) ,  Matsumoto Ken (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Matsumoto Ken (Seed Compounds Exploratory Unit for Drug Discovery Platform, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science, Japan)
Material： ACS Chemical Biology
Volume： 14  Issue： 8  Page： 1819-1828  Publication year： 2019 
JST Material Number： W5037A  ISSN： 1554-8937  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Thioviridamide, prethioviridam...

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Thesaurus term： sensitivity ,  Mitochondria ,  Adenoviridae ,  Apoptosis ,  *antitumor action ,  tumor cell ,  screening (inspection) ,  aminoacyl-tRNA synthetase ,  Transcriptome ,  *ribosome ,  synthase ,  *peptide ,  small hairpin RNA ,  *Thioamides ,  microorganism ,  animal virus
Semi thesaurus term： プロファイリング , 【Automatic Indexing@JST】

JST classification (3)： Enzyme in general  (EB09010D) ,  Peptides  (CF10080G) ,  Microorganism biochemistry  (EG03020N)

Terms in the title (6)： チオアミド ,  抗腫瘍性 ,  リボソーム ,  翻訳後修飾 ,  ペプチド ,  作用機序