Art

J-GLOBAL ID：201902275404764416   Reference number：19A0114994

Synthesis and characterization of ¹¹C-labeled benzyl amidine derivatives as PET radioligands for GluN2B subunit of the NMDA receptors

NMDA受容体のGluN2BサブユニットのPET放射性リガンドとしての11C標識ベンジルアミジン誘導体の合成と特性化【JST・京大機械翻訳】

Author (11)： Fuchigami Takeshi (Department of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan) ,  Fujimoto Noriko (Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan) ,  Haradahira Terushi (Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan) ,  Nojiri Yumiko (Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan) ,  Okauchi Takashi (Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan) ,  Maeda Jun (Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan) ,  Suhara Tetsuya (Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan) ,  Yamamoto Fumihiko (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Nakayama Morio (Department of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan) ,  Maeda Minoru (Daiichi University of Pharmacy, Fukuoka, Japan) ,  Mukai Takahiro (Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe, Japan)
Material： Journal of Labelled Compounds and Radiopharmaceuticals  (Journal of Labelled Compounds & Radiopharmaceuticals)
Volume： 61  Issue： 14  Page： 1095-1105  Publication year： 2018 
JST Material Number： B0864A  ISSN： 0362-4803  CODEN： JLCRD  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： GluN2B-containing NMDA recepto...

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Thesaurus term： Mus musculus ,  *characterization ,  in vitro experiment ,  *NMDA receptor ,  image processing ,  PET (tomography) ,  Metabolism ,  biodistribution ,  *subunit ,  precursor (substance) ,  brain disease ,  labeled compound ,  Methylation ,  *GluN2B ,  Myomorpha
Semi thesaurus term： 特異性 , 【Automatic Indexing@JST】

Author keywords (4)： benzyl amidines ,  GluN2B subunit ,  NMDA receptors ,  positron emission tomography (PET)

JST classification (5)： Basic research of diagnostic drugs  (GW20010P) ,  Labeled compounds  (CB10050N) ,  Receptors on cell membrane  (EF04030C) ,  Cell physiology in general  (EF02010S) ,  Molecular structure  (EB03020Y)

Terms in the title (8)： NMDA受容体 ,  GluN2B ,  サブユニット ,  PET ,  放射性リガンド ,  標識 ,  誘導体 ,  特性化