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J-GLOBAL ID：201902276269210770   Reference number：19A0735955

Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4

プレニル化されたquinolinカルボン酸誘導体はMKK4の阻害を介して神経細胞死を阻止する【JST・京大機械翻訳】

Author (8)： Ogura Masato (Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan) ,  Kikuchi Haruhisa (Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8678, Japan) ,  Shakespear Norshalena (Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan) ,  Suzuki Toshiyuki (Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan) ,  Yamaki Junko (Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan) ,  Homma Miwako K. (Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan) ,  Oshima Yoshiteru (Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8678, Japan) ,  Homma Yoshimi (Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan)
Material： Biochemical Pharmacology  (Biochem Pharmacol)
Volume： 162  Page： 109-122  Publication year： 2019 
JST Material Number： B0128A  ISSN： 0006-2952  CODEN： BCPCA6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The development of neuroprotec...

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Thesaurus term： interaction ,  amyloid beta-protein ,  Eumetopias jubata ,  in vitro experiment ,  neurotoxin ,  culture (biology) ,  *Cell Death ,  *Prenylation ,  kinase ,  Neurodegenerative Diseases ,  *MKK4 ,  Amyloid ,  glycoprotein ,  animal protein ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  primary amine
Semi thesaurus term： 神経変性 ,  阻害剤 ,  神経保護物質 , 【Automatic Indexing@JST】

Author keywords (5)： Neuronal cell death ,  Neurodegeneration ,  MAPK ,  Neurotoxin ,  Small molecule

JST classification (2)： Toxicity of organic compounds  (GZ02030Y) ,  Basic neurology  (GN01020W)

Substance index (1)： Glutamic acid

Terms in the title (7)： プレニル化 ,  カルボン酸 ,  誘導体 ,  MKK4 ,  阻害 ,  神経細胞死 ,  阻止