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J-GLOBAL ID：201902276915887334   Reference number：19A1474563

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice

ヒト化肝マウスにおけるNS3/4A阻害剤,NS5B阻害剤および非選択的抗ウイルス薬のうち2種類の薬物の併用はNS5A-p32欠失を伴うC型肝炎ウイルスに有効である

Author (17)： Doi Akira (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Hikita Hayato (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Kai Yugo (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Tahata Yuki (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Saito Yoshinobu (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Nakabori Tasuku (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Yamada Ryoko (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Kodama Takahiro (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Sakamori Ryotaro (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Murayama Asako (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Nitta Sayuri (Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan) ,  Asahina Yasuhiro (Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan) ,  Asahina Yasuhiro (Department of Liver Disease Control, Tokyo Medical and Dental University, Tokyo, Japan) ,  Suemizu Hiroshi (Department of Laboratory Animal Research, Central Institute for Experimental Animals, Kawasaki, Japan) ,  Tatsumi Tomohide (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan) ,  Kato Takanobu (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Takehara Tetsuo (Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan)
Material： Journal of Gastroenterology (Web)
Volume： 54  Issue： 5  Page： 449-458  Publication year： 2019 
JST Material Number： U1592A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *hepatitis C virus ,...
Semi thesaurus term： hepatitis C virus infection ,...

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Author keywords (5)： Direct-acting antiviral drug (DAA) ,  Resistance-associated substitutions (RASs) ,  Recombinant HCV ,  Humanized liver mice ,  Thymidine kinase transgene (TK-NOG) mice

JST classification (4)： Basic medicine on digestive system  (GH01020E) ,  Liver  (EJ06060J) ,  Genetic variation  (EC01030Y) ,  Physiology and pathogenicity of virus infection  (EG04042Y)

Substance index (7)： Elbasvir ,  Simeprevir ,  Sofosbuvir ,  BMS-790052 ,  Ribavirin ,  Ledipasvir ,  Verpatasvir

Terms in the title (10)： マウス ,  NS3 ,  阻害剤 ,  NS5B ,  抗ウイルス薬 ,  薬物 ,  併用 ,  NS5A ,  欠失 ,  C型肝炎ウイルス