Art

J-GLOBAL ID：201902280078894942   Reference number：19A0646509

Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice

抗CD11b抗体治療は関節炎傾向FcγRIIb欠損マウスにおける破骨細胞生成,炎症細胞浸潤および自己抗体産生を抑制する【JST・京大機械翻訳】

Author (8)： Ohtsuji Mareki (Department of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan) ,  Lin Qingshun (Department of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan) ,  Okazaki Hideki (Health and Life Science, Musashigaoka Junior College, Saitama, Japan) ,  Takahashi Kazuko (Faculty of Health and Welfare, Kanagawa University of Human Services, Yokosuka, Japan) ,  Amano Hirofumi (Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan) ,  Yagita Hideo (Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan) ,  Nishimura Hiroyuki (Department of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan) ,  Hirose Sachiko (Department of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan)
Material： Arthritis Research & Therapy (Web)
Volume： 20  Issue： 1  Page： 25  Publication year： 2018 
JST Material Number： U7412A  ISSN： 1478-6362  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Previously we established an a...

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Thesaurus term： *CD11b antigen ,  neutrophils ,  *osteoclast ,  *antibody formation ,  monocyte ,  *therapy ,  effect ,  rheumatoid arthritis ,  immunoglobulin G ,  spleen ,  *mouse(animal) ,  *autoantibody ,  interleukin 6 ,  macrophage ,  rat

Author keywords (5)： Rheumatoid arthritis ,  FcγRIIB deficiency ,  Osteoclast ,  Monocytes ,  B cell activation

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Immunological reaction in general  (ED03010T)

Reference (35)：

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• Arthritis Rheum.; Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues; RA Dodds, JR Connor, FH Drake, M Gowen; 42; 1999; 1588-1593; 10.1002/1529-0131(199908)42:8<1588::AID-ANR4>3.0.CO;2-S; citation_id=CR2
• Nature.; Osteoclast differentiation and activation; W Boyle, WS Simonet, DL Lacey; 423; 2003; 337-342; 10.1038/nature01658; citation_id=CR3
• Nat Rev Immunol.; Monocyte and macrophage heterogeneity; S Gordon, PR Taylor; 5; 2005; 953-964; 10.1038/nri1733; citation_id=CR4
• Nat Rev Rheumatol.; Osteoimmunology and the effect of the immune system on bone; H Takayanagi; 5; 2009; 667-676; 10.1038/nrrheum.2009.217; citation_id=CR5

Terms in the title (12)： CD11b ,  抗体 ,  治療 ,  関節 ,  傾向 ,  FcγRIIB ,  欠損 ,  マウス ,  破骨細胞 ,  炎症細胞浸潤 ,  自己 ,  抗体産生