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J-GLOBAL ID：201902282110560701   Reference number：19A1490941

Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid

非環式レチノイドによるMYCN陽性肝癌幹細胞標的化による肝細胞癌の予防【JST・京大機械翻訳】

Author (22)： Qin Xian-Yang (Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan) ,  Suzuki Harukazu (Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, 230-0045 Kanagawa, Japan) ,  Honda Masao (Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-0942 Ishikawa, Japan) ,  Okada Hikari (Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-0942 Ishikawa, Japan) ,  Kaneko Shuichi (Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-0942 Ishikawa, Japan) ,  Inoue Ikuyo (Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan) ,  Ebisui Etsuko (Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan) ,  Hashimoto Kosuke (Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, 230-0045 Kanagawa, Japan) ,  Carninci Piero (Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, 230-0045 Kanagawa, Japan) ,  Kanki Keita (Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago, 683-8503 Tottori, Japan) ,  Tatsukawa Hideki (Department of Basic Medicinal Sciences, Nagoya University Graduate School of Pharmaceutical Sciences, Nagoya, 464-8601 Aichi, Japan) ,  Ishibashi Naoto (Tokyo New Drug Research Laboratories, Pharmaceutical Division, KOWA Co. Ltd., 189-0022 Tokyo, Japan) ,  Masaki Takahiro (Department of Laboratory Medicine, The Jikei University School of Medicine, 105-8461 Tokyo, Japan) ,  Matsuura Tomokazu (Department of Laboratory Medicine, The Jikei University School of Medicine, 105-8461 Tokyo, Japan) ,  Kagechika Hiroyuki (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 101-0062 Tokyo, Japan) ,  Toriguchi Kan (Department of Surgery, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Hatano Etsuro (Department of Surgery, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Shirakami Yohei (Department of Gastroenterology, Graduate School of Medicine, Gifu University, 501-1194 Gifu, Japan) ,  Shiota Goshi (Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago, 683-8503 Tottori, Japan) ,  Shimizu Masahito (Department of Gastroenterology, Graduate School of Medicine, Gifu University, 501-1194 Gifu, Japan) ,  Moriwaki Hisataka (Department of Gastroenterology, Graduate School of Medicine, Gifu University, 501-1194 Gifu, Japan) ,  Kojima Soichi (Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 19  Page： 4969-4974  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Hepatocellular carcinoma (HCC)...

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Thesaurus term： therapy ,  human ,  transcription factor ,  Carcinogenesis ,  *targeting ,  Prognosis ,  *hepatocyte ,  biomarker ,  *hepatoma ,  vitamin A ,  Epithelial Cell Adhesion Molecule ,  beta Catenin ,  *Retinoids ,  *MYCN ,  Signal Transduction
Semi thesaurus term： cellular signal transduction , 【Automatic Indexing@JST】

Author keywords (5)： MYCN ,  hepatocellular carcinoma ,  cancer stem cell ,  transcriptome ,  acyclic retinoid

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Terms in the title (7)： 非環式レチノイド ,  MYCN ,  肝癌 ,  幹細胞 ,  標的化 ,  肝細胞癌 ,  予防