Art

J-GLOBAL ID：201902290662815848   Reference number：19A1067548

Effects of Vitamin K2 on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR

ヒト化PXRを有するマウスにおける胆汁酸合成およびグルコース恒常性に関与する遺伝子発現に及ぼすビタミンK2の影響【JST・京大機械翻訳】

Author (7)： Sultana Halima (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan) ,  Watanabe Kimika (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan) ,  Rana Md Masud (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan) ,  Takashima Rie (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan) ,  Ohashi Ai (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan) ,  Komai Michio (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan) ,  Shirakawa Hitoshi (Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan)
Material： Nutrients (Web)
Volume： 10  Issue： 8  Page： 982  Publication year： 2018 
JST Material Number： U7255A  ISSN： 2072-6643  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Pregnane X receptor (PXR) is a...

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Thesaurus term： DNA microarray ,  *gene ,  mRNA ,  wild type ,  *bile acid ,  HepG2 cell ,  homeostasis ,  *bile ,  *human(primates) ,  oral administration ,  *gene expression ,  physiology ,  drug metabolism ,  osteoporosis
Semi thesaurus term： リガンド , 【Automatic Indexing@JST】

Author keywords (5)： PXR ,  menaquinone 4 ,  bile homeostasis ,  energy homeostasis ,  gene expression

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Gene expression  (EC02040Q)

Reference (44)：

• Kliewer, S.A.; Moore, J.T.; Wade, L.; Staudinger, J.L.; Watson, M.A.; Jones, S.A.; McKee, D.D.; Oliver, B.B.; Willson, T.M.; Zetterstrom, R.H.; et al. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway. Cell 1998, 92, 73-82.
• Bertilsson, G.; Heidrich, J.; Svensson, K.; Asman, M.; Jendeberg, L.; Sydow-Backman, M.; Ohlsson, R.; Postlind, H.; Blomquist, P.; Berkenstam, A. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. USA 1998, 95, 12208-12213.
• Blumberg, B.; Sabbagh, W., Jr.; Juguilon, H.; Bolado, J., Jr.; van Meter, C.M.; Ong, E.S.; Evans, R.M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 1998, 12, 3195-3205.
• Igarashi, K.; Kitajima, S.; Aisaki, K.; Tanemura, K.; Taquahashi, Y.; Moriyama, N.; Ikeno, E.; Matsuda, N.; Saga, Y.; Blumberg, B.; et al. Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence. J. Toxicol. Sci. 2012, 37, 373-380.
• Guengerich, F.P. Cytochrome P-450 3A4: Regulation and role in drug metabolism. Ann. Rev. Pharmacol. Toxicol. 1999, 39, 1-17.

Terms in the title (6)： PXR ,  マウス ,  胆汁酸 ,  グルコース恒常性 ,  遺伝子発現 ,  ビタミンK2