Art

J-GLOBAL ID：202002216032504131   Reference number：20A0539985

DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF PYRILAMINE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

ヒストンデアセチラーゼ阻害剤としてのピリラミン誘導体の設計,合成および構造活性相関研究

Author (15)： HIRANAKA Seiya (Kansai Univ., Osaka, JPN) ,  HIRANAKA Seiya (RIKEN Center for Sustainable Resource Sci., Saitama, JPN) ,  ARATA Mayumi (RIKEN Center for Sustainable Resource Sci., Saitama, JPN) ,  NAKATA Akiko (RIKEN Center for Sustainable Resource Sci., Saitama, JPN) ,  TANAKA Akiko (RIKEN Center for Biosystems Dynamics Res., Kanagawa, JPN) ,  HASHIZUME Yoshinobu (RIKEN Program for Drug Discovery and Medical Technol. Platforms, Saitama, JPN) ,  KUDO Norio (RIKEN Center for Sustainable Resource Sci., Saitama, JPN) ,  ITO Akihiro (RIKEN Center for Sustainable Resource Sci., Saitama, JPN) ,  ITO Akihiro (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  YOSHIDA Minoru (RIKEN Center for Sustainable Resource Sci., Saitama, JPN) ,  YOSHIDA Minoru (Univ. Tokyo, Tokyo, JPN) ,  UESATO Shinichi (Kansai Univ., Osaka, JPN) ,  UESATO Shinichi (Osaka Univ. Pharmaceutical Sci., Osaka, JPN) ,  NAGAOKA Yasuo (Kansai Univ., Osaka, JPN) ,  SUMIYOSHI Takaaki (Kansai Univ., Osaka, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 101  Issue： 2  Page： 726-737  Publication year： Jan. 01, 2020 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *histone deacetylase ,...
Semi thesaurus term： Pyridines

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JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Other condensed derivatives of pyridine  (CF07097Y) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (2)： Trichostatin A ,  Mepyramine

Reference (8)：

• E. Seto and M. Yoshida, Cold Spring Harb. Perspect. Biol., 2014, 6, a08713.
• V. I. Gregoretti, M. Y. Lee, and V. H. Goodson, J. Mol. Biol., 2004, 338, 17.
• M. Yoshida, M. Kijima, M. Akita, and T. Beppu, J. Biol. Chem., 1990, 265, 17174.
• E. J. Bolden, J. M. Peart, and W. R. Johnstone, Nat. Rev. Drug Discov., 2006, 5, 269.
• P. A. Marks and W.-S. Xu, J. Cell. Biochem., 2009, 107, 600.

Terms in the title (6)： ヒストンデアセチラーゼ阻害剤 ,  ピリラミン ,  誘導体 ,  設計 ,  構造活性相関 ,  研究