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J-GLOBAL ID：202002225279407636   Reference number：20A1175615

Structural insights into the subtype-selective antagonist binding to the M₂ muscarinic receptor

M_2ムスカリン受容体へのサブタイプ選択的アンタゴニスト結合への構造的洞察【JST・京大機械翻訳】

Author (20)： Suno Ryoji (Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Lee Sangbae (Department of Molecular Imaging and Therapy, Beckman Research Institute of the City of Hope, Duarte, CA, USA) ,  Maeda Shoji (Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA) ,  Yasuda Satoshi (Graduate School of Science and Molecular Chirality Research Center, Chiba University, Inage, Chiba, Japan) ,  Yamashita Keitaro (RIKEN, SPring-8 Center, Hyogo, Japan) ,  Hirata Kunio (RIKEN, SPring-8 Center, Hyogo, Japan) ,  Hirata Kunio (Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), Kawaguchi, Saitama, Japan) ,  Horita Shoichiro (Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Tawaramoto Maki S. (Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Tsujimoto Hirokazu (Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Murata Takeshi (Graduate School of Science and Molecular Chirality Research Center, Chiba University, Inage, Chiba, Japan) ,  Murata Takeshi (Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), Kawaguchi, Saitama, Japan) ,  Kinoshita Masahiro (Institute of Advanced Energy and Graduate School of Energy Science, Kyoto University, Uji, Kyoto, Japan) ,  Yamamoto Masaki (RIKEN, SPring-8 Center, Hyogo, Japan) ,  Kobilka Brian K. (Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA) ,  Vaidehi Nagarajan (Department of Molecular Imaging and Therapy, Beckman Research Institute of the City of Hope, Duarte, CA, USA) ,  Iwata So (Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Iwata So (Japan Science and Technology Agency, Research Acceleration Program, Membrane Protein Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Kobayashi Takuya (Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Kobayashi Takuya (Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan)
Material： Nature Chemical Biology  (Nat Chem Biol)
Volume： 14  Issue： 12  Page： 1150-1158  Publication year： 2018 
JST Material Number： W2213A  ISSN： 1552-4450  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Human muscarinic rec...

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Thesaurus term： crystal structure ,  sodium ,  *receptor ,  mutation ,  human(primates) ,  cation ,  pharmacology ,  high-resolution ,  small molecule ,  *muscarinic receptor
Semi thesaurus term： 神経変性疾患 ,  G蛋白質共役型受容体 ,  分子動力学シミュレーション ,  *アンタゴニスト ,  残基 , 【Automatic Indexing@JST】

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Molecular structure  (EB03020Y)

Terms in the title (5)： ムスカリン受容体 ,  サブ ,  タイプ ,  アンタゴニスト ,  洞察