Art

J-GLOBAL ID：202002253453546947   Reference number：20A2023345

8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice

太平洋オキアミからの8-HEPE濃縮材料は,高コレステロール食給餌低密度リポ蛋白質(LDL)受容体欠損マウスにおける血漿コレステロールレベルおよび肝脂肪症を改善する

Author (5)： Saito Maki (Department of Patophysiology and Pharmacology, Iwate Medical University School of Pharmaceutical Sciences) ,  Ishida Nanae (Department of Patophysiology and Pharmacology, Iwate Medical University School of Pharmaceutical Sciences) ,  Yamada Hidetoshi (Iwate Biotechnology Research Center) ,  Ibi Miho (Department of Pathology, Iwate Medical University School of Dentistry) ,  Hirose Masamichi (Department of Patophysiology and Pharmacology, Iwate Medical University School of Pharmaceutical Sciences)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 6  Page： 919-924(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： ABCA1 ,...

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Author keywords (6)： 8-hydroxyeicosapentaenoic acid ,  dyslipidemia ,  N-3 polyunsaturated fatty acid ,  8-hydroxyeicosapentaenoic acid ,  dyslipidemia ,  N-3 polyunsaturated fatty acid

JST classification (4)： Basic research of drugs acting on lipid metabolism  (GW13040M) ,  Basic medicine on digestive system  (GH01020E) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Liver  (EJ06060J)

Substance index (1)： 8-HEPE

Reference (40)：

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• 4) Fleming JA, Kris-Etherton PM. The evidence for alpha-linolenic acid and cardiovascular disease benefits: comparisons with eicosapentaenoic acid and docosahexaenoic acid. Adv. Nutr., 5, 863S-876S (2014).
• 5) Wen YT, Dai JH, Gao Q. Effects of Omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Nutr. Metab. Cardiovasc. Dis., 24, 470-475 (2014).

Terms in the title (12)： 太平洋 ,  オキアミ ,  8-HEPE ,  濃縮 ,  高コレステロール食 ,  給餌 ,  低密度リポ蛋白質 ,  LDL ,  受容体欠損 ,  マウス ,  血漿コレステロール ,  肝脂肪症