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J-GLOBAL ID：202002254911555452   Reference number：20A1175769

Ligand binding to human prostaglandin E receptor EP₄ at the lipid-bilayer interface

脂質-二分子層界面におけるヒトプロスタグランジンE受容体EP_4へのリガンド結合【JST・京大機械翻訳】

Author (52)： Toyoda Yosuke (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Toyoda Yosuke (School of Medicine, Tsinghua University, Beijing, China) ,  Morimoto Kazushi (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Suno Ryoji (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Horita Shoichiro (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Yamashita Keitaro (RIKEN SPring-8 Center, Sayo-cho, Sayo-gun, Hyogo, Japan) ,  Hirata Kunio (RIKEN SPring-8 Center, Sayo-cho, Sayo-gun, Hyogo, Japan) ,  Sekiguchi Yusuke (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Yasuda Satoshi (Department of Chemistry, Graduate School of Science, Chiba University, Inage, Chiba, Japan) ,  Yasuda Satoshi (Institute of Advanced Energy, Kyoto University, Uji, Kyoto, Japan) ,  Shiroishi Mitsunori (Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan) ,  Shiroishi Mitsunori (Japan Science and Technology Agency (JST), Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Shimizu Tomoko (NB Health Laboratory Co. Ltd., Kita Ward Sapporo City, Hokkaido, Japan) ,  Urushibata Yuji (NB Health Laboratory Co. Ltd., Kita Ward Sapporo City, Hokkaido, Japan) ,  Kajiwara Yuta (Graduate School of Energy Science, Kyoto University, Uji, Kyoto, Japan) ,  Kajiwara Yuta (Molecular Profiling Research Center for Drug Discovery (MOLPROF), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan) ,  Inazumi Tomoaki (Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-Honmachi, Kumamoto, Japan) ,  Hotta Yunhon (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Asada Hidetsugu (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Asada Hidetsugu (JST, the Strategic Basic Research Program, Membrane Protein Crystallography Project, Kyoto, Japan) ,  Nakane Takanori (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Shiimura Yuki (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Shiimura Yuki (JST, the Strategic Basic Research Program, Membrane Protein Crystallography Project, Kyoto, Japan) ,  Nakagita Tomoya (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Tsuge Kyoshiro (Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-Honmachi, Kumamoto, Japan) ,  Yoshida Suguru (Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan) ,  Kuribara Tomoko (Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan) ,  Hosoya Takamitsu (Japan Science and Technology Agency (JST), Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Hosoya Takamitsu (Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan) ,  Sugimoto Yukihiko (Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-Honmachi, Kumamoto, Japan) ,  Sugimoto Yukihiko (Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan) ,  Nomura Norimichi (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Nomura Norimichi (JST, the Strategic Basic Research Program, Membrane Protein Crystallography Project, Kyoto, Japan) ,  Sato Miwa (Biomedical Department, Mitsui Knowledge Industry Co., Minato-ku, Tokyo, Japan) ,  Hirokawa Takatsugu (Japan Science and Technology Agency (JST), Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Hirokawa Takatsugu (Molecular Profiling Research Center for Drug Discovery (MOLPROF), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan) ,  Hirokawa Takatsugu (Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) ,  Kinoshita Masahiro (Institute of Advanced Energy, Kyoto University, Uji, Kyoto, Japan) ,  Murata Takeshi (Department of Chemistry, Graduate School of Science, Chiba University, Inage, Chiba, Japan) ,  Murata Takeshi (Japan Science and Technology Agency (JST), Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Takayama Kiyoshi (NB Health Laboratory Co. Ltd., Kita Ward Sapporo City, Hokkaido, Japan) ,  Yamamoto Masaki (RIKEN SPring-8 Center, Sayo-cho, Sayo-gun, Hyogo, Japan) ,  Yamamoto Masaki (Japan Science and Technology Agency (JST), Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Narumiya Shuh (Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan) ,  Narumiya Shuh (Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan) ,  Iwata So (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Iwata So (RIKEN SPring-8 Center, Sayo-cho, Sayo-gun, Hyogo, Japan) ,  Iwata So (JST, the Strategic Basic Research Program, Membrane Protein Crystallography Project, Kyoto, Japan) ,  Kobayashi Takuya (Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Kobayashi Takuya (Japan Science and Technology Agency (JST), Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Japan) ,  Kobayashi Takuya (JST, the Strategic Basic Research Program, Membrane Protein Crystallography Project, Kyoto, Japan) ,  Kobayashi Takuya (Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan)
Material： Nature Chemical Biology  (Nat Chem Biol)
Volume： 15  Issue： 1  Page： 18-26  Publication year： 2019 
JST Material Number： W2213A  ISSN： 1552-4450  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Prostaglandin E rece...

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Thesaurus term： *interface (surface) ,  crystal structure ,  docking ,  antibody ,  *lipid ,  *receptor ,  human ,  binding site ,  complex (substance) ,  Allosteric Site ,  *ligand binding ,  ligand binding domain
Semi thesaurus term： アゴニスト ,  アンタゴニスト ,  残基 , 【Automatic Indexing@JST】

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Molecular structure  (EB03020Y)

Terms in the title (6)： 脂質 ,  二分子層 ,  界面 ,  ヒト ,  プロスタグランジンE受容体 ,  リガンド結合