Art

J-GLOBAL ID：202002256157581234   Reference number：20A0620935

Unveiling Two Consecutive Hydroxylations: Mechanisms of Aromatic Hydroxylations Catalyzed by Flavin-Dependent Monooxygenases for the Biosynthesis of Actinorhodin and Related Antibiotics

2つの連続ヒドロキシル化の解明:アクチノロジンおよび関連抗生物質の生合成のためのフラビン依存モノオキシゲナーゼにより触媒される芳香族ヒドロキシル化の機構【JST・京大機械翻訳】

Author (10)： Hashimoto Makoto (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Taguchi Takaaki (National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan) ,  Ishikawa Kazuki (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Mori Ryuichiro (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Hotta Akari (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Watari Susumu (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Katakawa Kazuaki (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Kumamoto Takuya (Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8553, Japan) ,  Okamoto Susumu (National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan) ,  Ichinose Koji (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan)
Material： ChemBioChem
Volume： 21  Issue： 5  Page： 623-627  Publication year： 2020 
JST Material Number： W1258A  ISSN： 1439-4227  CODEN： CBCHFX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Flavin-dependent monooxygenase...

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Thesaurus term： *single donor oxygenase ,  dihydroxylation ,  *antibiotics ,  *catalyst ,  functionalization ,  *biosynthesis ,  in vitro experiment ,  reaction mechanism ,  Bacteria ,  intermediate ,  Streptomyces coelicolor ,  cofactor ,  *hydroxylation ,  *monooxygenase ,  substrate (biochemistry) ,  *antibacterial drug ,  *antimicrobial drug ,  *drug ,  microorganism ,  Actinomycetales

Author keywords (5)： actinorhodin ,  aromatic hydroxylation ,  biosynthesis ,  flavin-dependent monooxygenases ,  reaction mechanisms

JST classification (2)： Enzyme in general  (EB09010D) ,  Microorganism biochemistry  (EG03020N)

Terms in the title (8)： ヒドロキシル化 ,  アクチノロジン ,  抗生物質 ,  生合成 ,  フラビン ,  モノオキシゲナーゼ ,  触媒 ,  芳香族