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J-GLOBAL ID：202002268653839013   Reference number：20A2484681

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16^high Cells In Vivo

p16レポーターマウスの生成とin vivoでのp16high細胞の特性化と標的【JST・京大機械翻訳】

Author (39)： Omori Satotaka (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Wang Teh-Wei (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Johmura Yoshikazu (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kanai Tomomi (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Nakano Yasuhiro (Laboratory of Stem Cell Therapy, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Kido Taketomo (Laboratory of Stem Cell Therapy, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Susaki Etsuo A. (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Susaki Etsuo A. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-5241, Japan) ,  Nakajima Takuya (Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-0022, Japan) ,  Shichino Shigeyuki (Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-0022, Japan) ,  Ueha Satoshi (Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-0022, Japan) ,  Ozawa Manabu (Laboratory of Reproductive Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yokote Kisho (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kumamoto Soichiro (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Nishiyama Atsuya (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Sakamoto Takeharu (Department of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan) ,  Yamaguchi Kiyoshi (Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Hatakeyama Seira (Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Shimizu Eigo (Division of Health Medical Intelligence, Human Genome Center, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Katayama Kotoe (Division of Health Medical Intelligence, Human Genome Center, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yamada Yasuhiro (Division of Stem Cell Pathology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yamada Yasuhiro (AMED-CREST, AMED, 1-7-1 Otemachi, Tokyo 100-0004, Japan) ,  Yamazaki Satoshi (Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yamazaki Satoshi (Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan) ,  Iwasaki Kanako (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Miyoshi Chika (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Funato Hiromasa (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Funato Hiromasa (Department of Anatomy, Faculty of Medicine, Toho University, 5-21-16 Omorinishi, Ota-ku, Tokyo 143-8540, Japan) ,  Yanagisawa Masashi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yanagisawa Masashi (Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA) ,  Ueno Hiroo (Department of Stem Cell Pathology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan) ,  Imoto Seiya (Division of Health Medical Intelligence, Human Genome Center, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Furukawa Yoichi (Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yoshida Nobuaki (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Matsushima Kouji (Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-0022, Japan) ,  Ueda Hiroki R. (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Ueda Hiroki R. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-5241, Japan) ,  Miyajima Atsushi (Laboratory of Stem Cell Therapy, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Nakanishi Makoto (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan)
Material： Cell Metabolism
Volume： 32  Issue： 5  Page： 814-828.e6  Publication year： 2020 
JST Material Number： W3108A  ISSN： 1550-4131  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Cell senescence plays a key ro...

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Thesaurus term： Half-Life ,  Fatty Liver ,  epithelium ,  Phenotype ,  *senile change ,  characterization ,  Endothelium ,  pathogenesis ,  cell aging ,  cell infiltration ,  Transcriptome analysis ,  single cell ,  cell type ,  mouse model ,  membrane and film ,  histomembrane
Semi thesaurus term： 非アルコール性脂肪性肝炎 , 【Automatic Indexing@JST】

Author keywords (5)： senescence ,  p16Ink4a ,  single-cell transcriptomics ,  NASH ,  aging

JST classification (2)： Aging and death  (EJ16040S) ,  Biological function  (EB03040U)

Terms in the title (5)： p16 ,  マウス ,  細胞 ,  特性化 ,  標的