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J-GLOBAL ID：202002288935344742   Reference number：20A0781900

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

H3K9とH3K27の協調的脱メチル化は内皮細胞の急速な炎症反応に必要である【JST・京大機械翻訳】

Author (32)： Higashijima Yoshiki (Department of Bioinformational Pharmacology, Tokyo Medical and Dental University, Tokyo, Japan) ,  Higashijima Yoshiki (Isotope Science Center, The University of Tokyo, Tokyo, Japan) ,  Matsui Yusuke (Division of Biomedical and Health Informatics, Graduate school of medicine, Nagoya university, Nagoya, Japan) ,  Shimamura Teppei (Division of Systems Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Nakaki Ryo (Rhelixa Inc., Tokyo, Japan) ,  Nagai Nao (Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan) ,  Tsutsumi Shuichi (Division of Genome Sciences, RCAST, The University of Tokyo, Tokyo, Japan) ,  Abe Yohei (Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Link Verena M (Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Link Verena M (Faculty of Biology, Division of Evolutionary Biology, Ludwig-Maximilian University of Munich, Munich, Germany) ,  Link Verena M (Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA) ,  Osaka Mizuko (Department of Nutrition in Cardiovascular Disease, Tokyo Medical and Dental University, Tokyo, Japan) ,  Osaka Mizuko (Department of Life Sciences and Bioethics, Tokyo Medical and Dental University, Tokyo, Japan) ,  Yoshida Masayuki (Department of Life Sciences and Bioethics, Tokyo Medical and Dental University, Tokyo, Japan) ,  Watanabe Ryo (Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Tanaka Toshihiro (Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Tanaka Toshihiro (Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan) ,  Taguchi Akashi (Isotope Science Center, The University of Tokyo, Tokyo, Japan) ,  Miura Mai (Isotope Science Center, The University of Tokyo, Tokyo, Japan) ,  Miura Mai (Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, Japan) ,  Ruan Xiaoan (Jackson Laboratory for Genomic Medicine, Farmington, CT, USA) ,  Li Guoliang (Agricultural Bioinformatics Key Laboratory of Hubei Province, Hubei Engineering Technology Research Center of Agricultural Big Data, College of Informatics, Huazhong Agricultural University, Wuhan, China) ,  Inoue Tsuyoshi (Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan) ,  Nangaku Masaomi (Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan) ,  Kimura Hiroshi (Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan) ,  Furukawa Tetsushi (Department of Bioinformational Pharmacology, Tokyo Medical and Dental University, Tokyo, Japan) ,  Aburatani Hiroyuki (Division of Genome Sciences, RCAST, The University of Tokyo, Tokyo, Japan) ,  Wada Youichiro (Isotope Science Center, The University of Tokyo, Tokyo, Japan) ,  Ruan Yijun (Jackson Laboratory for Genomic Medicine, Farmington, CT, USA) ,  Glass Christopher K (Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Glass Christopher K (Department of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Kanki Yasuharu (Isotope Science Center, The University of Tokyo, Tokyo, Japan)
Material： EMBO Journal  (EMBO J)
Volume： 39  Issue： 7  Page： e103949  Publication year： 2020 
JST Material Number： A0911B  ISSN： 0261-4189  CODEN： EMJODG  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Histone H3 lysine-9 di-methyla...

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Thesaurus term： *demethylation ,  gene expression ,  *inflammation ,  NF-kappaB ,  *methylation ,  interaction ,  *endothelial cell ,  human(primates) ,  steric conformation ,  capture ,  gene ,  TNF alpha ,  methyltransferase ,  chromatin ,  pharmacology

Author keywords (5)： chromatin conformation ,  endothelial dysfunction ,  histone demethylase ,  repressive histone mark ,  super enhancer

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (4)： 協調 ,  脱メチル化 ,  内皮細胞 ,  炎症反応