Art

J-GLOBAL ID：202002289868085195   Reference number：20A1907942

Brexanolone: A new drug for postpartum depression

周産期メンタルヘルスの今 産後うつ病の新規治療薬 brexanolone

Author (1)： HASHIMOTO KENJI (千葉大 社会精神保健教育研究セ)
Material： 精神医学  (Clinical Psychiatry)
Volume： 62  Issue： 9  Page： 1253-1258  Publication year： Sep. 15, 2020 
JST Material Number： Z0446B  ISSN： 0488-1281  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *depression(disease) ,...
Semi thesaurus term： mental health ,...

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JST classification (3)： Drug therapy(=pharmacotherapy)for mental disorders  (GR04020D) ,  Clinical gynecology and obstetrics in general  (GS01030W) ,  Clinical application of psychotropic drugs  (GW03110J)

Substance index (1)： Allopregnanolone

Reference (20)：

• Frieder A, Fersh M, Hainline R, et al : Pharmacotherapy of postpartum depression : current approaches and novel drug development. CNS Drugs 33 : 265-282, 2019
• Paul SM, Pinna G, Guidotti A : Allopregnanolone : from molecular pathophysiology to therapeutics. A historical perspective. Neurobiol Stress 12 : 100215, 2020
• Osborne LM, Gispen F, Sanyal A, et al : Lower allopregnanolone during pregnancy predicts postpartum depression : an exploratory study. Psychoneuroendocrinology 79 : 116-121, 2017
• Shirayama Y, Muneoka K, Fukumoto M, et al : Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial : prefrontal cortex, produces antidepressant effects on the learned helplessness rats. Hippocampus 21 : 1105-1113, 2011
• Shirayama Y, Fujita Y, Oda Y, et al : Allopregnanolone induces antidepressant-like effects through BDNF-TrkB signaling independent from AMPA receptor activation in a rat learned helplessness model of depression. Behav Brain Res 390 : 112670, 2020

Terms in the title (4)： 周産期 ,  メンタルヘルス ,  産後うつ病 ,  治療薬