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J-GLOBAL ID：202102213842806818   Reference number：21A0417000

Clinical Outcomes of Off-Label Underdosing of Direct Oral Anticoagulants After Ablation for Atrial Fibrillation Subanalysis of the AF Frontier Ablation Registry

AF Frontier Ablation Registryの心房細動サブ解析におけるアブレーション後の直接経口抗凝固薬のオフラベル低用量の臨床転帰

Author (39)： Wakamatsu Yuji (Division of Cardiology, Nihon University Itabashi Hospital) ,  Nagashima Koichi (Division of Cardiology, Nihon University Itabashi Hospital) ,  Watanabe Ryuta (Division of Cardiology, Nihon University Itabashi Hospital) ,  Arai Masaru (Division of Cardiology, Nihon University Itabashi Hospital) ,  Yokoyama Katsuaki (Department of Cardiology, Nihon University Hospital) ,  Matsumoto Naoya (Department of Cardiology, Nihon University Hospital) ,  Otsuka Takayuki (Department of Cardiology, The Cardiovascular Institute) ,  Suzuki Shinya (Department of Cardiology, The Cardiovascular Institute) ,  Hirata Akio (Cardiovascular Division, Osaka Police Hospital) ,  Murakami Masato (Divison of Cardiology, Shonan-Kamakura General Hospital) ,  Takami Mitsuru (Osaka Saiseikai Nakatsu Hospital) ,  Kimura Masaomi (Divison of Cardiology, Hirosaki University Hospital) ,  Fukaya Hidehira (Kitasato University Hospital) ,  Nakahara Shiro (Dokkyo Medical University Saitama Medical Center) ,  Kato Takeshi (Kanazawa University Hospital) ,  Hayashi Hiroshi (Nippon Medical Hospital) ,  Iwasaki Yu-ki (Nippon Medical Hospital) ,  Shimizu Wataru (Nippon Medical Hospital) ,  Nakajima Ikutaro (St. Marianna University School of Medicine Hospital) ,  Harada Tomoo (St. Marianna University School of Medicine Hospital) ,  Koyama Junjiroh (Saiseikai Kumamoto Hospital) ,  Okumura Ken (Saiseikai Kumamoto Hospital) ,  Tokuda Michifumi (Tokyo Jikei University School of Medicine Hospital) ,  Yamane Teiichi (Tokyo Jikei University School of Medicine Hospital) ,  Tanimoto Kojiro (National Hospital Organization Tokyo Medical Center) ,  Momiyama Yukihiko (National Hospital Organization Tokyo Medical Center) ,  Nonoguchi Noriko (Kyorin University Hospital) ,  Soejima Kyoko (Kyorin University Hospital) ,  Ejima Koichiro (Tokyo Women’s Medical University Hospital) ,  Hagiwara Nobuhisa (Tokyo Women’s Medical University Hospital) ,  Harada Masahide (Fujita University Health Hospital) ,  Sonoda Kazumasa (Tokyo Rinkai Hospital) ,  Inoue Masaru (Ishikawa Prefectural Central Hospital) ,  Kumagai Koji (Gunma Cardiovascular Center) ,  Hayashi Hidemori (Juntendo University) ,  Yazaki Yoshinao (Tokyo Medical University Hospital) ,  Satomi Kazuhiro (Tokyo Medical University Hospital) ,  Watari Yuji (Teikyo University) ,  Okumura Yasuo (Division of Cardiology, Nihon University Itabashi Hospital)
Material： International Heart Journal (Web)
Volume： 61  Issue： 6  Page： 1165-1173(J-STAGE)  Publication year： 2020 
JST Material Number： U1357A  ISSN： 1349-3299  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： CHA2DS2-VASc score ,...

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Author keywords (5)： Anticoagulation ,  Catheter ablation ,  Bleeding ,  Stroke ,  Mortality

JST classification (2)： Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M) ,  Postoperative treatment and prognosis  (GC07050M)

Reference (28)：

• 1. Odutayo A, Wong CX, Hsiao AJ, Hopewell S, Altman DG, Emdin CA. Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: Systematic review and meta-analysis. BMJ 2016; 354: i4482.
• 2. Piccini JP, Lopes RD, Kong MH, Hasselblad V, Jackson K, Al-Khatib SM. Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: A meta-analysis of randomized, controlled trials. Circ Arrhythm Electrophysiol 2009; 2: 626-33.
• 3. Cosedis Nielsen J, Johannessen A, Raatikainen P, et al. Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation. N Engl J Med 2012; 367: 1587-95.
• 4. Okumura Y, Nagashima K, Arai M, et al. AF Ablation Frontier Registry. Current status and clinical outcomes of oral anticoagulant discontinuation after ablation for atrial fibrillation in Japan - Findings from the AF Frontier Ablation Registry. Circ J 2019; 83: 2418-27.
• 5. Steinberg BA, Shrader P, Thomas L, et al. Off-label dosing of non-vitamin K antagonist oral anticoagulants and adverse outcomes: The ORBIT-AF II Registry. J Am Coll Cardiol 2016; 68: 2597-604.

Terms in the title (8)： AF ,  心房細動 ,  サブ ,  解析 ,  アブレーション ,  直接経口抗凝固薬 ,  低用量 ,  臨床転帰