Art

J-GLOBAL ID：202102221228688805   Reference number：21A0217674

(-)-Epigallocatechin-3-gallate inhibits RANKL-induced osteoclastogenesis via downregulation of NFATc1 and suppression of HO-1-HMGB1-RAGE pathway

(-)-エピガロカテキン-3-没食子酸塩はNFATc1のダウンレギュレーションとHO-1-HMGB1-RAGE経路の抑制を介してRANKL誘発破骨細胞形成を阻害する

Author (7)： NISHIOKU Tsuyoshi (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University) ,  KUBO Toshiki (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University) ,  KAMADA Tsukushi (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University) ,  OKAMOTO Kuniaki (Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University) ,  TSUKUBA Takayuki (Division of Oral Pharmacology, Nagasaki University Graduate School of Biomedical Sciences) ,  UTO Takuhiro (Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University) ,  SHOYAMA Yukihiro (Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University)
Material： Biomedical Research (Web)
Volume： 41  Issue： 6  Page： 269-277(J-STAGE)  Publication year： 2020 
JST Material Number： U1102A  ISSN： 1880-313X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tannin ,...
Semi thesaurus term： genetic regulation ,...

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JST classification (3)： Basic research of other drugs acting on metabolism  (GW13060I) ,  Cell physiology in general  (EF02010S) ,  Biological function  (EB02020R)

Substance index (1)： (-)-Epigallocatechin gallate

Reference (35)：

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• Chen ST, Kang L, Wang CZ, Huang PJ, Huang HT, et al. (2019) (-)-Epigallocatechin-3-gallate decreases osteoclastogenesis via modulation of RANKL and osteoprotegrin. Molecules 24, 156.
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Terms in the title (11)： エピガロカテキン ,  NFATc1 ,  ダウンレギュレーション ,  HO-1 ,  HMGB1 ,  RAGE ,  経路 ,  RANKL ,  誘発 ,  破骨細胞形成 ,  阻害