Art

J-GLOBAL ID：202102221879845725   Reference number：21A0217479

Effect of Tricaprin on Cardiac Proteome in a Mouse Model for Triglyceride Deposit Cardiomyovasculopathy

中性脂肪蓄積心筋血管症のマウスモデルにおける心臓プロテオームに及ぼすトリカプリンの影響

Author (10)： Hara Yasuhiro (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Zhang Bo (Department of Biochemistry, Fukuoka University Medical School) ,  Suzuki Akira (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Yamaguchi Satoshi (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University) ,  Adachi Jun (Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition) ,  Tomonaga Takeshi (Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition) ,  Yasunaga Shin'ichiro (Department of Biochemistry, Fukuoka University Medical School) ,  Saku Keijiro (General Medical Research Center, Fukuoka University Medical School) ,  Aoyama Toshiaki (Food Biotechnology Platform Promoting Project, New industry Creation Hatchery Center (NICHe) at Tohoku University) ,  Hirano Ken-ichi (Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University)
Material： Journal of Oleo Science  (J Oleo Sci)
Volume： 69  Issue： 12  Page： 1569-1577(J-STAGE)  Publication year： 2020 
JST Material Number： G0238A  ISSN： 1345-8957  CODEN： JOSOAP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： lipase ,...
Semi thesaurus term： lipid metabolic improvement action ,...

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Author keywords (10)： TGCV ,  triglyceride ,  tricaprin ,  heart ,  proteomics ,  TGCV ,  triglyceride ,  tricaprin ,  heart ,  proteomics

JST classification (3)： Edible fats and oils,margarines  (FJ09010C) ,  Basic research of cardioactive drugs  (GW07020N) ,  Metabolism and nutrition of lipids  (EJ02034Q)

Substance index (1)： Tricaprin

Reference (32)：

• 1) Hirano, K.; Ikeda, Y.; Zaima, N.; Sakata, Y.; Matsumiya, G. Triglyceride deposit cardiomyovasculopathy. N. Engl. J. Med. 359, 2396-2398i2008).
• 2) Hirano, K.; Tanaka, T.; Ikeda, Y.; Yamaguchi, S.; Zaima, N.; Kobayashi, K.; Suzuki, A.; Sakata, Y.; Sakata, Y.; Kobayashi, K.; Toda, T.; Fukushima, N.; Ishibashi-Ueda, H.; Tavian, D.; Nagasaka, H.; Hui, S.P.; Chiba, H.; Sawa, Y.; Hori, M. Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-gamma in patients with triglyceride deposit cardiomyovasculopathy. Biochem. Biophys. Res. Commun. 443, 574-579 (2014).
• 3) Li, M.; Hirano, K.I.; Ikeda, Y.; Higashi, M.; Hashimoto, C.; Zhang, B.; Kozawa, J.; Sugimura, K.; Miyauchi, H.; Suzuki, A.; Hara, Y.; Takagi, A.; Ikeda, Y.; Kobayashi, K.; Futsukaichi, Y.; Zaima, N.; Yamaguchi, S.; Shrestha, R.; Nakamura, H.; Kawaguchi, K.; Sai, E.; Hui, S.P.; Nakano, Y.; Sawamura, A.; Inaba, T.; Sakata, Y.; Yasui, Y.; Nagasawa, Y.; Kinugawa, S.; Shimada, K.; Yamada, S.; Hao, H.; Nakatani, D.; Ide, T.; Amano, T.; Naito, H.; Nagasaka, H.; Kobayashi, K.; Japan, T.s.g. Triglyceride deposit cardiomyovasculopathy: A rare cardiovascular disorder. Orphanet J. Rare Dis. 14, 134 (2019).
• 4) Zimmermann, R.; Strauss, J.G.; Haemmerle, G.; Schoiswohl, G.; Birner-Gruenberger, R.; Riederer, M.; Lass, A.; Neuberger, G.; Eisenhaber, F.; Hermetter, A.; Zechner, R. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306, 1383-1386 (2004).
• 5) Terada, S.; Sekine, S.; Aoyama, T. Dietary intake of medium- and long-chain triacylglycerols prevents the progression of hyperglycemia in diabetic ob/ob mice. J. Oleo Sci. 64, 683-688 (2015).

Terms in the title (5)： 中性脂肪蓄積心筋血管症 ,  マウスモデル ,  心臓 ,  プロテオーム ,  トリカプリン