Art

J-GLOBAL ID：202102229457075796   Reference number：21A0197264

Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine

G蛋白質バイアスμ-リガンドオリジンの迅速開始および短時間作用のさらなる研究【JST・京大機械翻訳】

Author (22)： Mori Tomohisa (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Takemura Yoshinori (Department of Anesthesiology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama, 930-0194, Japan) ,  Arima Takamichi (Department of Pharmacy, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan) ,  Iwase Yoshiyuki (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Narita Michiko (Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan) ,  Narita Michiko (Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan) ,  Miyano Kanako (Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan) ,  Hamada Yusuke (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Hamada Yusuke (Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan) ,  Suda Yukari (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Suda Yukari (Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan) ,  Matsuzawa Akinobu (Department of Synthetic Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Sugita Kazuyuki (Department of Synthetic Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Matsumura Shoki (Institute of Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Sasaki Shigeru (Institute of Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Yamauchi Takayasu (Institute of Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Higashiyama Kimio (Institute of Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Uezono Yasuhito (Department of Pain Control Research, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan) ,  Yamazaki Mitsuaki (Department of Anesthesiology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama, 930-0194, Japan) ,  Kuzumaki Naoko (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Narita Minoru (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Narita Minoru (Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 534  Page： 988-994  Publication year： 2021 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： TRV130 (oliceridine), a G prot...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0197264&from=J-GLOBAL&jstjournalNo=B0118A") }}

Thesaurus term： impedance ,  sensitization (immunology) ,  Sciatic Nerve ,  side effect ,  *narcotic analgesic ,  pain ,  Pharmacology ,  ligature ,  opiate receptor ,  analgesic ,  antinociceptive action ,  ferret ,  hot plate ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide
Semi thesaurus term： 痛覚過敏 , 【Automatic Indexing@JST】

Author keywords (6)： Oliceridine ,  G protein-coupled signaling pathway ,  Antinociception ,  μ-opioid receptor ,  Side effects ,  Breakthrough pain

JST classification (1)： Receptors on cell membrane  (EF04030C)

Substance index (1)： cAMP

Terms in the title (4)： G蛋白質 ,  バイアス ,  短時間 ,  研究