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J-GLOBAL ID：202102242577281311   Reference number：21A0437410

A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells

ゲノムスケールCRISPRスクリーンはマウス胃上皮細胞のWnt依存性更新を調節する因子を明らかにする【JST・京大機械翻訳】

Author (9)： Murakami Kazuhiro (Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma-machi, 924-1192 Kanazawa, Japan) ,  Terakado Yumi (Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma-machi, 924-1192 Kanazawa, Japan) ,  Saito Kikue (Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma-machi, 924-1192 Kanazawa, Japan) ,  Jomen Yoshie (Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma-machi, 924-1192 Kanazawa, Japan) ,  Takeda Haruna (Laboratory of Molecular Genetics, National Cancer Center Research Institute, Chuo-ku, 104-0045 Tokyo, Japan) ,  Oshima Masanobu (Division of Genetics, Cancer Research Institute, Nano-Life Science Institute, Kanazawa University, Kakuma-machi, 920-1192 Kanazawa, Japan) ,  Barker Nick (Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma-machi, 924-1192 Kanazawa, Japan) ,  Barker Nick (Epithelial Stem Cell Group, Agency for Science, Technology and Research Institute of Molecular and Cell Biology, 138673 Singapore, Singapore) ,  Barker Nick (Agency for Science, Technology and Research Institute of Medical Biology, 276543 Singapore, Singapore)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 118  Issue： 4  Page： e2016806118  Publication year： 2021 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： An ability to safely harness t...

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Thesaurus term： gene ,  gastric mucosa ,  *epithelium ,  differentiation(biology) ,  phosphorylation ,  clustering ,  *genome ,  adult(development) ,  screening(inspection) ,  interleukin ,  stem cell
Semi thesaurus term： オルガノイド ,  ex vivo実験 ,  Wntシグナル ,  *Wnt蛋白質 , 【Automatic Indexing@JST】

Author keywords (5)： CRISPR-Cas9 ,  genome-wide screening ,  Wnt ,  tissue stem cells ,  Lgr5

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Terms in the title (11)： ゲノム ,  スケール ,  CRISPR ,  スクリーン ,  マウス ,  胃上皮細胞 ,  Wnt ,  依存性 ,  更新 ,  調節 ,  因子